Gene diversity of chimpanzee ABO blood group genes elucidated from intron 6 sequences

被引:7
作者
Kitano, T
Noda, R
Sumiyama, K
Ferrell, RE
Saitou, N [1 ]
机构
[1] Natl Inst Genet, Lab Evolutionary Genet, Mishima, Shizuoka 4118540, Japan
[2] Univ Pittsburgh, Dept Human Genet, Pittsburgh, PA USA
关键词
D O I
10.1093/jhered/91.3.211
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The human and nonhuman primate ABO blood group gene shows relatively large numbers of nucleotide differences around the exon 7 region. In this study we determined intron 6 sequences for 9 alleles of common chimpanzee and for 3 alleles of bonobo to estimate nucleotide diversities among them. Sequence length polymorphisms are observed in this region as a repeat appears one to five times. From a phylogenetic network of intron 6 sequences of ABO blood group genes for humans, common chimpanzee, and bonobo, parallel substitutions and/or some kinds of convergent events are predicted in the chimpanzee lineage. We also estimated nucleotide diversities for common chimpanzee and bonobo ABO blood group genes; these values were 0.219% and 0.208%, respectively.
引用
收藏
页码:211 / 214
页数:4
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