New insights into the thyroid-stimulating hormone receptor - The major antigen of Graves' disease

被引：23

作者：

Graves, PN ^{[1
]}

Davies, TF ^{[1
]}

机构：

[1] Mt Sinai Sch Med, Dept Med, Div Endocrinol & Metab, New York, NY 10029 USA

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2000年 / 29卷 / 02期

关键词：

D O I：

10.1016/S0889-8529(05)70131-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The receptor for thyroid-stimulating hormone is one of the most interesting hormone-binding sites because of its close association with common human diseases, including thyroid nodules and Graves' hyperthyroidism. This article discusses the structure and biosynthetic processing of this elusive glycoprotein, whose paucity and instability have impeded its isolation from natural sources. Topics include cleavage and subunit structure, variant species, and structural modeling, the thyroid-stimulating hormone receptor as the major autoantigen in Graves' disease, and a summary of recent efforts to replicate the symptoms of this uniquely human disease in animal models.

引用

页码：267 / +

页数：21

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