A natural classification of the basic helix-loop-helix class of transcription factors

被引：532

作者：

Atchley, WR ^{[1
]}

Fitch, WM ^{[1
]}

机构：

[1] UNIV CALIF IRVINE,DEPT ECOL & EVOLUTIONARY BIOL,IRVINE,CA 92717

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1997年 / 94卷 / 10期

关键词：

D O I：

10.1073/pnas.94.10.5172

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A natural (evolutionary) classification is provided for 242 basic helix-loop-helix (bHLH) motif-containing proteins, Phylogenetic analyses of amino acid sequences describe the patterns of evolutionary change within the motif and delimit evolutionary lineages. These evolutionary lineages represent well known functional groups of proteins and can be further arranged into five groups based on binding to DNA at the hexanucleotide E-box, the amino acid patterns in other components of the motif, and the presence/absence of a leucine zipper, The hypothesized ancestral amino acid sequence for the bHLH transcription factor family is given together with the ancestral sequences of the subgroups, It is suggested that bHLH proteins containing a leucine zipper are not a natural, monophyletic group.

引用

页码：5172 / 5176

页数：5

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