Induction of gelatinase B and MCP-2 in baboons during sublethal and lethal bacteraemia

被引:35
作者
Paemen, L
Jansen, PM
Proost, P
VanDamme, J
Opdenakker, G
Hack, E
Taylor, FB
机构
[1] CATHOLIC UNIV LEUVEN,REGA INST MED RES,LAB MOL IMMUNOL,B-3000 LOUVAIN,BELGIUM
[2] UNIV AMSTERDAM,EXPT & CLIN IMMUNOL LAB,AMSTERDAM,NETHERLANDS
[3] NETHERLANDS RED CROSS,BLOOD TRANSFUS SERV,CENT LAB,AMSTERDAM,NETHERLANDS
[4] OKLAHOMA MED RES FDN,OKLAHOMA CITY,OK 73104
关键词
gelatinase B; MCP-2; sepsis; baboons;
D O I
10.1006/cyto.1996.0183
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
intravenous injection of sublethal or lethal doses of Escherichia coli in baboons resulted in increased serum levels of the matrix metalloprotease gelatinase B and the chemokine monocyte chemotactic protein 2 (MCP-2), In both animal models, gelatinase B appeared faster than MCP-2. After sublethal challenge, serum levels of gelatinase B and MCP-2 were found to be correlated, reaching peak levels between 2 and 4h after bacterial challenge, After lethal challenge, however, MCP-2 tended to increase until 10 h, The kinetics of appearance suggest induction of release of gelatinase B and de novo synthesis and secretion of MCP-2, both by endotoxin. (C) 1997 Academic Press Limited.
引用
收藏
页码:412 / 415
页数:4
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