One session of high frequency repetitive transcranial magnetic stimulation (rTMS) to the right prefrontal cortex transiently reduces cocaine craving

被引:187
作者
Camprodon, Joan Albert
Martinez-Raga, Jose
Alonso-Alonso, Miguel
Shih, Mei-Chiung
Pascual-Leone, Alvaro
机构
[1] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Neurol,Ctr Noninvas Brain Simulat, Boston, MA 02215 USA
[2] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA
[3] Childrens Hosp, Clin Res Program, Boston, MA 02115 USA
关键词
cocaine; addiction; craving; transcranial magnetic stimulation (TMS); dorsolateral prefrontal cortex (DLPFC);
D O I
10.1016/j.drugalcdep.2006.06.002
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Background: Cocaine dependence is a public health problem affecting 2 million individuals in USA. Craving is a predictor of subsequent cocaine use and is related to changes in brain activity in networks involving the prefrontal cortex. Methods: We investigated the efficacy of one session of high frequency repetitive transcranial magnetic stimulation (rTMS) to reduce craving in cocaine addicted subjects. Six patients underwent two sessions of 10 Hz rTMS over left or right dorsolateral prefrontal cortex (DLPFC). Before, immediately after and 4 h after rTMS we measured craving using visual analogue scales. Results: Right. but not left, DLPFC stimulation significantly reduced craving over time (F(2,10)= 11.07, p=0.0029). The reduction was 19% (13.4-24.6%) from baseline and disappeared after 4 h. The interaction of time by site of stimulation for craving was also significant (F(2,25) = 6.13, p = 0.0068). Conclusion: One session of 10 Hz rTMS over right, but not left, DLPFC transiently reduces craving in cocaine dependent individuals. These results highlight the potential of non-invasive neuromodulation as a therapeutic tool for cocaine addiction. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:91 / 94
页数:4
相关论文
共 21 条
[1]   Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective [J].
Bechara, A .
NATURE NEUROSCIENCE, 2005, 8 (11) :1458-1463
[2]   Neural systems and cue-induced cocaine craving [J].
Bonson, KR ;
Grant, SJ ;
Contoreggi, CS ;
Links, JM ;
Metcalfe, J ;
Weyl, HL ;
Kurian, V ;
Ernst, M ;
London, ED .
NEUROPSYCHOPHARMACOLOGY, 2002, 26 (03) :376-386
[3]   High-frequency repetitive transcranial magnetic stimulation decreases cigarette smoking [J].
Eichhammer, P ;
Johann, M ;
Kharraz, A ;
Binder, H ;
Pittrow, D ;
Wodarz, N ;
Hajak, G .
JOURNAL OF CLINICAL PSYCHIATRY, 2003, 64 (08) :951-953
[4]   Cue-induced cocaine craving: Neuroanatomical specificity for drug users and drug stimuli [J].
Garavan, H ;
Pankiewicz, J ;
Bloom, A ;
Cho, JK ;
Sperry, L ;
Ross, TJ ;
Salmeron, BJ ;
Risinger, R ;
Kelley, D ;
Stein, EA .
AMERICAN JOURNAL OF PSYCHIATRY, 2000, 157 (11) :1789-1798
[5]  
George MS, 1999, HUM PSYCHOPHARM CLIN, V14, P161, DOI 10.1002/(SICI)1099-1077(199904)14:3<161::AID-HUP73>3.0.CO
[6]  
2-2
[7]   Transcranial magnetic stimulation in the treatment of depression [J].
Gershon, AA ;
Dannon, PN ;
Grunhaus, L .
AMERICAN JOURNAL OF PSYCHIATRY, 2003, 160 (05) :835-845
[8]   Drug addiction and its underlying neurobiological basis: Neuroimaging evidence for the involvement of the frontal cortex [J].
Goldstein, RZ ;
Volkow, ND .
AMERICAN JOURNAL OF PSYCHIATRY, 2002, 159 (10) :1642-1652
[9]   Applications of TMS to therapy in psychiatry [J].
Lisanby, SH ;
Kinnunen, LH ;
Crupain, MJ .
JOURNAL OF CLINICAL NEUROPHYSIOLOGY, 2002, 19 (04) :344-360
[10]   Functional magnetic resonance imaging of human brain activation during cue-induced cocaine craving [J].
Maas, LC ;
Lukas, SE ;
Kaufman, MJ ;
Weiss, RD ;
Daniels, SL ;
Rogers, VW ;
Kukes, TJ ;
Renshaw, PF .
AMERICAN JOURNAL OF PSYCHIATRY, 1998, 155 (01) :124-126