Total synthesis of theopederin D

被引：36

作者：

Green, Michael E. ^{[1
]}

Rech, Jason C. ^{[1
]}

Floreancig, Paul E. ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 38期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

C-C activation; chemoselectivity; cyclization; radical ions; total synthesis;

D O I：

10.1002/anie.200802548

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) The transformation is complete! The total synthesis of theopederin D (see structure), a potent cytotoxin, has been achieved through oxidative cleavage of a carbon-carbon bond. Other key transformations include an acid-mediated functionalization of a tetrahydrofuranol, a synselective glycal epoxide ring-opening, and an asymmetric aldehyde/acid chloride condensation. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7317 / 7320

页数：4

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