Memory protective effect of indomethacin against electroconvulsive shock-induced retrograde amnesia in rats

被引：32

作者：

Rao, SK

Andrade, C

Reddy, K

Madappa, KN

Thyagarajan, S

Chandra, S

机构：

[1] Royal Victoria Infirm, Mental Hlth Unit, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England

[2] Natl Inst Mental Hlth & Neurosci, Dept Psychopharmacol, Bangalore 560029, Karnataka, India

[3] Natl Inst Mental Hlth & Neurosci, Cent Anim Res Facil, Bangalore 560029, Karnataka, India

来源：

BIOLOGICAL PSYCHIATRY | 2002年 / 51卷 / 09期

关键词：

indomethacin; nonsteroidal antiinflammatory drugs (NSAIDs); electroconvulsive shocks; memory; amnesia; rats;

D O I：

10.1016/S0006-3223(01)01219-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: Nonsteroidal antiinflammatory drugs (NSAIDs) have been suggested to retard cognitive decrements in patients with Alzheimer's disease. We postulated that NSAIDs also may protect acute disruption of memory. Methods: We studied the effect of indomethacin (4 mg/kg/day) administered daily for 19 days on retrograde amnesia induced by two once-daily electroconvulsive shocks in rats. Results: Indomethacin produced statistically significant prolongation of recall latency in a passive avoidance task using a step-down apparatus. Conclusions: Our study suggests that NSAIDs may prevent memory disruption through other mechanisms apart front attenuating chronic inflammation. In patients receiving electroconvulsive therapy, as in those diagnosed with Alzheimer's disease, antiinflammatory drugs may hold promise in the attenuation of cognitive impairments.

引用

页码：770 / 773

页数：4

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