Cellular mechanisms of infarct size reduction with ischemic preconditioning - Role of calcium?

被引：27

作者：

Przyklenk, K

Simkhovich, BZ

Bauer, B

Hata, K

Zhao, L

Elliott, GT

Kloner, RA

机构：

[1] Hosp Good Samaritan, Inst Heart, Los Angeles, CA 90017 USA

[2] Univ So Calif, Dept Med, Cardiol Sect, Los Angeles, CA 90017 USA

[3] RIBI Immunochem Res Inc, Hamilton, MT 59840 USA

来源：

HEART IN STRESS | 1999年 / 874卷

关键词：

D O I：

10.1111/j.1749-6632.1999.tb09236.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Brief episodes of ischemia protect or "precondition" the heart and reduce infarct size caused by a subsequent sustained ischemic insult. Despite a decade of intensive investigation, the cellular mechanism(s) responsible for this paradoxical protection remain poorly understood. In this review, we focus on the emerging concept that alterations in intracellular calcium homeostasis mag participate in either triggering and/or mediating Infarct size reduction with preconditioning.

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收藏

页码：192 / 210

页数：19

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