Elevated serum S-100B levels in children with temporal lobe epilepsy

被引:43
作者
Calik, Mustafa [1 ]
Abuhandan, Mahmut [2 ]
Sonmezler, Abdurrahman [4 ]
Kandemir, Hasan [5 ]
Oz, Ibrahim [7 ]
Taskin, Abdullah [3 ]
Selek, Sahabettin [3 ]
Iscan, Akin [6 ]
机构
[1] Harran Univ, Sch Med, Dept Pediat Neurol, TR-63100 Sanliurfa, Turkey
[2] Harran Univ, Sch Med, Dept Pediat, TR-63100 Sanliurfa, Turkey
[3] Harran Univ, Sch Med, Dept Biochem & Clin Biochem, TR-63100 Sanliurfa, Turkey
[4] Harran Univ, Sch Med, Dept Neurol, TR-63100 Sanliurfa, Turkey
[5] Harran Univ, Sch Med, Dept Child & Adolescent Psychiat, TR-63100 Sanliurfa, Turkey
[6] BezmialemVakif Univ, Fac Med, Dept Pediat Neurol, Istanbul, Turkey
[7] Nigde Childrens Hosp, Dept Biochem & Clin Biochem, Nigde, Turkey
来源
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY | 2013年 / 22卷 / 02期
关键词
Temporal lobe epilepsy; S-100B level; Biochemical marker; Children; NEURON-SPECIFIC ENOLASE; S100B; PROTEIN; MARKERS; BLOOD;
D O I
10.1016/j.seizure.2012.10.012
中图分类号
R74 [神经病学与精神病学];
学科分类号
100204 [神经病学];
摘要
Purpose: An elevated level of S-100B in serum is generally considered to be a biochemical marker of nervous tissue damage. According to our knowledge, no studies have evaluated the serum S-100B protein concentration in children with temporal lobe epilepsy. The objective of this study was to measure the serum levels of S-100B protein in pediatric cases with temporal epilepsy. Methods: This case-controlled cross-sectional study was performed at the Department of Pediatric Neurology, Harran University School of Medicine, Sanliurfa, in Turkey. Serum S-100B protein levels were studied in 19 (12 females, 7 males) children with temporal lobe epilepsy and in 25 (15 females, 10 males) healthy control subjects. Serum samples were collected within 30 min after a complex partial seizure, and serum S-100B protein levels were measured with an electrochemiluminescence immunoassay for the quantification of protein (ECLIA kit, Roche (R) Diagnostics, Germany). Results: The mean serum concentration of S-100B protein was 0.12 +/- 0.02 mu g/L in the temporal lobe epilepsy group and 0.07 +/- 0.01 mu g/L in the control group. The patients showed significantly elevated S-100B protein levels compared with healthy controls (P < 0.001). Conclusion: Our data suggest that increased S-100B protein levels in the serum might reflect neuronal damage in the brains of children with temporal lobe epilepsy. These results do confirm the previous findings of elevated S-100B protein levels in adult patients with temporal lobe epilepsy. (C) 2012 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:99 / 102
页数:4
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