Elevated plasma S100B concentration is associated with mesial temporal lobe epilepsy in Han Chinese: A case-control study

被引：48

作者：

Lu, Changfeng ^{[1
,2
]}

Li, Jun ^{[3
]}

Sun, Wei ^{[1
]}

Feng, Lei ^{[4
]}

Li, Liping ^{[1
]}

Liu, Aihua ^{[1
]}

Li, Junjie ^{[1
]}

Mao, Wei ^{[1
]}

Wei, Hua ^{[1
]}

Gao, Lehong ^{[1
]}

Zhang, Xiating ^{[1
]}

Huang, Zhaoyang ^{[1
]}

Meng, Xianghong ^{[1
]}

Wang, Yuping ^{[1
]}

机构：

[1] Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing 100053, Peoples R China

[2] Capital Med Univ, Tongren Hosp, Dept Neurol, Beijing 100730, Peoples R China

[3] Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China

[4] Natl Univ Singapore, Dept Psychol Med, Yong Loo Lin Sch Med, Singapore 117548, Singapore

来源：

NEUROSCIENCE LETTERS | 2010年 / 484卷 / 02期

关键词：

Mesial temporal lobe epilepsy; S100B; Gliosis; Hippocampal sclerosis; Gender; Intelligence quotient; ALZHEIMERS-DISEASE; PROTEIN; SERUM; S100-BETA; GLIOSIS; NEURONS; SURGERY; INJURY; BLOOD;

D O I：

10.1016/j.neulet.2010.08.036

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Mesial temporal lobe epilepsy (MTLE) is a common type of intractable epilepsy characterized by astroglial gliosis. The S100B was viewed as an astrocyte marker and experimental studies indicated that S100B might be involved in the pathophysiology of temporal lobe epilepsy. In this study, we measured plasma S100B levels by ELISA in 28 patients with MTLE and 28 healthy controls and found that patients showed significantly elevated S100B levels compared with healthy controls (P = 0.018). Moreover, S100B levels were significantly higher in female patients than those in male patients (P = 0.027). These results suggest that S100B may be a biomarker of MTLE. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

收藏

页码：139 / 142

页数：4

相关论文

共 28 条

[1]

S-100β protects cultured neurons against glutamate- and staurosporine-induced damage and is involved in the antiapoptotic action of the 5 HT1A-receptor agonist, Bay x 3702 [J].

Ahlemeyer, B ;

Beier, H ;

Semkova, I ;

Schaper, C ;

Krieglstein, J .

BRAIN RESEARCH, 2000, 858 (01) :121-128

[2]

S100B/RAGE-dependent activation of microglia via NF-κB and AP-1 Co-regulation of COX-2 expression by S100B, IL-1β and TNF-α [J].

Bianchi, Roberta ;

Giambanco, Ileana ;

Donato, Rosario .

NEUROBIOLOGY OF AGING, 2010, 31 (04) :665-677

[3]

Hippocampal pathology in refractory temporal lobe epilepsy - T2-weighted signal change reflects dentate gliosis [J].

Briellmann, RS ;

Kalnins, RM ;

Berkovic, SF ;

Jackson, GD .

NEUROLOGY, 2002, 58 (02) :265-271

[4]

Hippocampal abnormalities and seizure recurrence after antiepileptic drug withdrawal [J].

Cardoso, T. A. M. ;

Coan, A. C. ;

Kobayashi, E. ;

Guerreiro, C. A. M. ;

Li, L. M. ;

Cendes, F. .

NEUROLOGY, 2006, 67 (01) :134-136

[5]

Serum levels of S100B and NSE proteins in Alzheimer's disease patients [J].

Chaves, Marcia L. ;

Camozzato, Ana L. ;

Ferreira, Eduardo D. ;

Piazenski, Isabel ;

Kochhann, Renata ;

Dall'lgna, Oscar ;

Mazzini, Guilherme S. ;

Souza, Diogo O. ;

Portela, Luis V. .

JOURNAL OF NEUROINFLAMMATION, 2010, 7

[6]

Cellular injury and neuroinflammation in children with chronic intractable epilepsy [J].

Choi, Jieun ;

Nordli, Douglas R., Jr. ;

Alden, Tord D. ;

DiPatri, Arthur, Jr. ;

Laux, Linda ;

Kelley, Kent ;

Rosenow, Joshua ;

Schuele, Stephan U. ;

Rajaram, Veena ;

Koh, Sookyong .

JOURNAL OF NEUROINFLAMMATION, 2009, 6

[7]

Long lasting sex-specific effects upon behavior and S100b levels after maternal separation and exposure to a model of post-traumatic stress disorder in rats [J].

Diehl, Luisa Amalia ;

Silveira, Patricia Pelufo ;

Leite, Marina C. ;

Crema, Leonardo Machado ;

Portella, Andre Krumel ;

Billodre, Mauro Nor ;

Nunes, Edelvan ;

Henriques, Thiago P. ;

Fidelix-da-Silva, Linda Brenda ;

Heis, Marta D. ;

Goncalves, Carlos Alberto ;

Quillfeldt, Jorge Alberto ;

Dalmaz, Carla .

BRAIN RESEARCH, 2007, 1144 :107-116

[8]

S100B-mediated protection against the pro-apoptotic effects of ethanol on fetal rhombencephalic neurons [J].

Druse, Mary J. ;

Gillespie, Roberta A. ;

Tajuddin, Nuzhath F. ;

Rich, Megan .

BRAIN RESEARCH, 2007, 1150 :46-54

[9]

Long-term prognosis and psychosocial outcomes after surgery for MTLE [J].

Dupont, Sophie ;

Tanguy, Marie-Laure ;

Clemenceau, Stephane ;

Adam, Claude ;

Hazemann, Paule ;

Baulac, Michel .

EPILEPSIA, 2006, 47 (12) :2115-2124

[10]

Long-term outcome after temporal lobe epilepsy surgery in 434 consecutive adult patients Clinical article [J].

Elsharkawy, Alaa Eldin ;

Alabbasi, Abdel Hamid ;

Pannek, Heinz ;

Oppel, Falk ;

Schulz, Reinhard ;

Hoppe, Mathias ;

Hamad, Ana Paula ;

Nayel, Mohamed ;

Issa, Ahmed ;

Ebner, Alois .

JOURNAL OF NEUROSURGERY, 2009, 110 (06) :1135-1146