Improvement of mechanical properties of poly(DL-lactide) films by blending of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)

被引：77

作者：

Gao, Y ^{[1
]}

Kong, L ^{[1
]}

Zhang, L ^{[1
]}

Gong, YD ^{[1
]}

Chen, GQ ^{[1
]}

Zhao, NM ^{[1
]}

Zhang, XF ^{[1
]}

机构：

[1] Tsinghua Univ, State Key Lab Biomembrane & Membrane Biotechnol, Dept Biol Sci & Technol, Beijing 100084, Peoples R China

来源：

EUROPEAN POLYMER JOURNAL | 2006年 / 42卷 / 04期

基金：

中国国家自然科学基金;

关键词：

poly(3-hydroxybutyrate-co-3-hydroxyhexanoate); poly(DL-lactide); blends; mechanical property;

D O I：

10.1016/j.eurpolymj.2005.09.028

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) and poly(DL-lactide) (PDLLA) were blended at different ratios in an attempt to form a biomaterial with suitable properties for nerve regeneration. FT-IR and X-ray analysis showed that the blending of the PDLLA component did not alter the helical structure of PHBHHx, but did lead to a reduction of crystallinity. Differential scanning calorimetry (DSC) analysis indicated that the two polymers were immiscible in the melted state. The mechanical properties of certain composite films were more desirable than those of unblended PDLLA films. Blends consisting of PDLLA and PHBHHx at ratios of 2:1 and 1:2 exhibited a lower elastic modulus and a higher elongation at break compared to unblended PDLLA. ELISA results indicated that the amount of fibronectin adsorbed on composite films was much higher than the amount adsorbed on PDLLA film. The results of this study demonstrate the feasibility of using PDLLA/PHBHHx blended materials for biomedical applications. (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：764 / 775

页数：12

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