Molecular mechanisms of developmental timing in C-elegans and Drosophila
被引:258
作者:
Thummel, CS
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机构:
Univ Utah, Dept Human Genet, Howard Hughes Med Inst, Salt Lake City, UT 84112 USAUniv Utah, Dept Human Genet, Howard Hughes Med Inst, Salt Lake City, UT 84112 USA
Thummel, CS
[1
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机构:
[1] Univ Utah, Dept Human Genet, Howard Hughes Med Inst, Salt Lake City, UT 84112 USA
Characterization of the heterochronic genes has provided a strong foundation for understanding the molecular mechanisms of developmental timing in C. elegans. In apparent contrast, studies of developmental timing in Drosophila have demonstrated a central role for gene cascades triggered by the steroid hormone ecdysone. In this review, I survey the molecular mechanisms of developmental timing in C. elegans and Drosophila and outline how common regulatory pathways are beginning to emerge.