Viral nanoparticles donning a paramagnetic coat: Conjugation of MRI contrast agents to the MS2 capsid

被引：159

作者：

Anderson, Elizabeth A.

Isaacman, Steven

Peabody, David S.

Wang, Edwin Y.

Canary, James W.

Kirshenbaum, Kent

机构：

[1] NYU, Dept Chem, New York, NY 10003 USA

[2] NYU, Dept Radiol, Sch Med, New York, NY 10016 USA

[3] Univ New Mexico, Hlth Sci Ctr, Dept Mol Genet & Microbiol, Albuquerque, NM 87131 USA

来源：

NANO LETTERS | 2006年 / 6卷 / 06期

关键词：

D O I：

10.1021/nl060378g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A nanoparticle magnetic resonance imaging (MRI) contrast agent was developed by conjugation of more than 500 gadolinium chelate groups onto a viral capsid. The high density of paramagnetic centers and slow tumbling rate of modified MS2 capsids provided enhanced T-1 relaxivities up to 7200 mM(-1) s(-1) per particle. A bimodal imaging agent was generated by sequential conjugation of fluorescein and Gd3+ chelate. These results illustrate the potential for engineering natural protein assemblies to address bionanotechnology applications.

引用

页码：1160 / 1164

页数：5

共 38 条

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