Role of human mast cells and basophils in bronchial asthma

被引:48
作者
Marone, G [1 ]
Triggiani, M [1 ]
Genovese, A [1 ]
De Paulis, A [1 ]
机构
[1] Univ Naples Federico II, Div Clin Immunol & Allergy, Ctr Basic & Clin Immunol Res, Sch Med, I-80131 Naples, Italy
来源
ADVANCES IN IMMUNOLOGY, VOL 88 | 2005年 / 88卷
关键词
D O I
10.1016/S0065-2776(05)88004-6
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Mast cells and basophils are the only cells expressing the tetrameric (0072) structure of the high affinity receptor for IgE (Fc epsilon RI) and synthesizing histamine in humans. Human Fc epsilon RI+ cells are conventionally considered primary effector cells of bronchial asthma. There is now compelling evidence that these cells differ immunologically, biochemically, and pharmacologically, which suggests that they might play distinct roles in the appearance and fluctuation of the asthma phenotype. Recent data have revealed the complexity of the involvement of human mast cells and basophils in asthma and have shed light on the control of recruitment and activation of these cells in different lung compartments. Preliminary evidence suggests that these cells might not always be detrimental in asthma but, under some circumstances, they might exert a protective effect by modulating certain aspects of innate and acquired immunity and allergic inflammation.
引用
收藏
页码:97 / 160
页数:64
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