PDT in clinics: Indications, results, and markets

被引:11
作者
Patrice, T [1 ]
Olivier, D [1 ]
Bourre, L [1 ]
机构
[1] Hop Laennec, Dept Laser, F-44093 Nantes, France
关键词
photodynamic therapy; PDT; cancer; Barrett's esophagus; ENT; glioblastomas; age-related degenerescence; cholangiocarcinoma; actinic keratose;
D O I
10.1615/JEnvironPatholToxicolOncol.v25.i1-2.300
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
Photodynamic therapy (PDT) is based on the selective light activation of an exogenously given drug to patients. PDT acts mainly on cell membranes either of neovascular endothelial cells or of cancer cells leading to cancer cell death. Six drugs are now marketed based on clinical assays in various indications, which showed a clear cost efficiency as compared to other classical procedures. PDT is easy to handle and can be performed in medical installations fitting the conditions of health care in developing countries. Its cost effectiveness could represent an appropriate solution to the increasing number of cancers of various origin. However despite all the clinical results now available, PDT development remains slow. The reasons for this situation include cost of development, intellectual property, and competition between pharmaceutical companies.
引用
收藏
页码:467 / 485
页数:19
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