Calcium Handling Abnormalities in Atrial Fibrillation as a Target for Innovative Therapeutics

被引：100

作者：

Dobrev, Dobromir ^{[1
]}

Nattel, Stanley ^{[2
,3
,4
,5
]}

机构：

[1] Tech Univ Dresden, Fac Med, Dept Pharmacol & Toxicol, D-01307 Dresden, Germany

[2] McGill Univ, Dept Pharmacol & Therapeut, Montreal, PQ, Canada

[3] Univ Montreal, Montreal, PQ, Canada

[4] Montreal Heart Inst, Dept Med, Montreal, PQ H1T 1C8, Canada

[5] Montreal Heart Inst, Res Ctr, Montreal, PQ H1T 1C8, Canada

来源：

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | 2008年 / 52卷 / 04期

基金：

加拿大健康研究院;

关键词：

calcium handling; atrial fibrillation; remodeling; ryanodine; phospholamban;

D O I：

10.1097/FJC.0b013e318171924d

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Atrial electrical and structural alterations (remodeling) have emerged as key elements in the development of the atrial fibrillation (AF) substrate. Evidence points to abnormalities in intracellular Ca2+ (calcium) handing as crucial links in AF-initiating focal activity and in perpetuation by rapidly firing foci and reentry. This review focuses on the molecular basis of altered Ca2+ handling in AF, with the goal of providing new insights into molecular effective antiarrhythmic therapy.

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收藏

页码：293 / 299

页数：7

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