Calcium Handling Abnormalities in Atrial Fibrillation as a Target for Innovative Therapeutics

被引：100

作者：

Dobrev, Dobromir ^{[1
]}

Nattel, Stanley ^{[2
,3
,4
,5
]}

机构：

[1] Tech Univ Dresden, Fac Med, Dept Pharmacol & Toxicol, D-01307 Dresden, Germany

[2] McGill Univ, Dept Pharmacol & Therapeut, Montreal, PQ, Canada

[3] Univ Montreal, Montreal, PQ, Canada

[4] Montreal Heart Inst, Dept Med, Montreal, PQ H1T 1C8, Canada

[5] Montreal Heart Inst, Res Ctr, Montreal, PQ H1T 1C8, Canada

来源：

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | 2008年 / 52卷 / 04期

基金：

加拿大健康研究院;

关键词：

calcium handling; atrial fibrillation; remodeling; ryanodine; phospholamban;

D O I：

10.1097/FJC.0b013e318171924d

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Atrial electrical and structural alterations (remodeling) have emerged as key elements in the development of the atrial fibrillation (AF) substrate. Evidence points to abnormalities in intracellular Ca2+ (calcium) handing as crucial links in AF-initiating focal activity and in perpetuation by rapidly firing foci and reentry. This review focuses on the molecular basis of altered Ca2+ handling in AF, with the goal of providing new insights into molecular effective antiarrhythmic therapy.

引用

收藏

页码：293 / 299

页数：7

相关论文

共 105 条

[11] ANGIOTENSIN-II INCREASES NOREPINEPHRINE RELEASE FROM ATRIA BY ACTING ON ANGIOTENSIN SUBTYPE-1 RECEPTORS [J].

BRASCH, H ;

SIEROSLAWSKI, L ;

DOMINIAK, P .

HYPERTENSION, 1993, 22 (05) :699-704

[12] PKC-α regulates cardiac contractility and propensity toward heart failure [J].

Braz, JC ;

Gregory, K ;

Pathak, A ;

Zhao, W ;

Sahin, B ;

Klevitsky, R ;

Kimball, TF ;

Lorenz, JN ;

Nairn, AC ;

Liggett, SB ;

Bodi, I ;

Wang, S ;

Schwartz, A ;

Lakatta, EG ;

DePaoli-Roach, AA ;

Robbins, J ;

Hewett, TE ;

Bibb, JA ;

Westfall, MV ;

Kranias, EG ;

Molkentin, JD .

NATURE MEDICINE, 2004, 10 (03) :248-254

[13] Activation of proteolysis by calpains and structural changes in human paroxysmal and persistent atrial fibrillation [J].

Brundel, BJJM ;

Ausma, J ;

van Gelder, IC ;

Van Der Want, JJL ;

van Gilst, WH ;

Crijns, HJGM ;

Henning, RH .

CARDIOVASCULAR RESEARCH, 2002, 54 (02) :380-389

[14]

Brundel BJJM, 2001, CIRCULATION, V103, P684

[15] Evolution of the atrial fibrillation substrate in experimental congestive heart failure: angiotensin-dependent and -independent pathways [J].

Cardin, S ;

Li, DS ;

Thorin-Trescases, N ;

Leung, TK ;

Thorin, E ;

Nattel, S .

CARDIOVASCULAR RESEARCH, 2003, 60 (02) :315-325

[16] IMMUNOLOCALIZATION OF SARCOLEMMAL DIHYDROPYRIDINE RECEPTOR AND SARCOPLASMIC RETICULAR TRIADIN AND RYANODINE RECEPTOR IN RABBIT VENTRICLE AND ATRIUM [J].

CARL, SL ;

FELIX, K ;

CASWELL, AH ;

BRANDT, NR ;

BALL, WJ ;

VAGHY, PL ;

MEISSNER, G ;

FERGUSON, DG .

JOURNAL OF CELL BIOLOGY, 1995, 129 (03) :673-682

[17] Atrial glutathione content, calcium current, and contractility [J].

Carnes, Cynthia A. ;

Janssen, Paul M. L. ;

Ruehr, Mary L. ;

Nakayama, Hitomi ;

Nakayama, Tomohiro ;

Haase, Hannelore ;

Bauer, John Anthony ;

Chung, Mina K. ;

Fearon, Ian M. ;

Gillinov, A. Marc ;

Hamlin, Robert L. ;

Van Wagoner, David R. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (38) :28063-28073

[18] Type 1 phosphatase, a negative regulator of cardiac function [J].

Carr, AN ;

Schmidt, AG ;

Suzuki, Y ;

del Monte, F ;

Sato, Y ;

Lanner, C ;

Breeden, K ;

Jing, SL ;

Allen, PB ;

Greengard, P ;

Yatani, A ;

Hoit, BD ;

Grupp, IL ;

Hajjar, RJ ;

DePaoli-Roach, AA ;

Kranias, EG .

MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (12) :4124-4135

[19] Maximum phosphorylation of the cardiac ryanodine receptor at serine-2809 by protein kinase A produces unique modifications to channel gating and conductance not observed at lower levels of phosphorylation [J].

Carter, Simon ;

Colyer, John ;

Sitsapesan, Rebecca .

CIRCULATION RESEARCH, 2006, 98 (12) :1506-1513

[20] Functional diversity of protein phosphatase-1, a cellular economizer and reset button [J].

Ceulemans, H ;

Bollen, M .

PHYSIOLOGICAL REVIEWS, 2004, 84 (01) :1-39

← 1 2 3 4 5 6 7 8 9 10 →