Chemerin Is an Antimicrobial Agent in Human Epidermis

被引：63

作者：

Banas, Magdalena ^{[1
]}

Zabieglo, Katarzyna ^{[1
]}

Kasetty, Gopinath ^{[4
]}

Kapinska-Mrowiecka, Monika ^{[5
]}

Borowczyk, Julia ^{[2
]}

Drukala, Justyna ^{[2
]}

Murzyn, Krzysztof ^{[3
]}

Zabel, Brian A. ^{[6
]}

Butcher, Eugene C. ^{[7
]}

Schroeder, Jens M. ^{[8
]}

Schmidtchen, Artur ^{[4
]}

Cichy, Joanna ^{[1
]}

机构：

[1] Jagiellonian Univ, Dept Immunol, Fac Biochem Biophys & Biotechnol, Krakow, Poland

[2] Jagiellonian Univ, Fac Biochem Biophys & Biotechnol, Dept Cell Biol, Krakow, Poland

[3] Jagiellonian Univ, Fac Biochem Biophys & Biotechnol, Dept Computat Biophys & Bioinformat, Krakow, Poland

[4] Lund Univ, Div Dermatol & Venerol, Dept Clin Sci, Lund, Sweden

[5] Zeromski Hosp, Dept Dermatol, Krakow, Poland

[6] Vet Affairs Palo Alto Hlth Care Syst, Palo Alto Inst Res & Educ, Palo Alto, CA USA

[7] Stanford Univ, Sch Med, Stanford, CA 94305 USA

[8] Univ Hosp Schleswig Holstein, Dept Dermatol, Kiel, Germany

来源：

PLOS ONE | 2013年 / 8卷 / 03期

基金：

美国国家卫生研究院;

关键词：

ANTIBIOTIC PEPTIDE; STRATUM-CORNEUM; DENDRITIC CELLS; DISEASED SKIN; PH GRADIENT; IN-VIVO; RECRUITMENT; ACTIVATION; RECEPTOR; PROTEIN;

D O I：

10.1371/journal.pone.0058709

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Chemerin, a chemoattractant ligand for chemokine-like receptor 1 (CMKLR1) is predicted to share similar tertiary structure with antibacterial cathelicidins. Recombinant chemerin has antimicrobial activity. Here we show that endogenous chemerin is abundant in human epidermis, and that inhibition of bacteria growth by exudates from organ cultures of primary human skin keratinocytes is largely chemerin-dependent. Using a panel of overlapping chemerin-derived synthetic peptides, we demonstrate that the antibacterial activity of chemerin is primarily mediated by Val 66 -Pro 85, which causes direct bacterial lysis. Therefore, chemerin is an antimicrobial agent in human skin.

引用

页数：8

共 37 条

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