HLA-DQB10304-DRB10408 haplotype associated with insulin-dependent diabetes mellitus in populations in the eastern Baltic region

被引：8

作者：

Ilonen, J

Koskinen, S

Nejentsev, S

Sjoroos, M

Knip, M

Schwartz, EI

Adojaan, B

Kovalchuk, L

Sochnevs, A

机构：

[1] UNIV TURKU,DEPT BIOTECHNOL,FIN-20520 TURKU,FINLAND

[2] UNIV TURKU,TURKU IMMUNOL CTR,FIN-20520 TURKU,FINLAND

[3] PAEDIAT MED INST,DEPT MED GENET,ST PETERSBURG,RUSSIA

[4] UNIV OULU,DEPT PAEDIAT,OULU,FINLAND

[5] TARTU STATE HOSP,DEPT ENDOCRINOL,TARTU,ESTONIA

[6] MED ACAD LATVIA,INST IMMUNOL,RIGA,LATVIA

来源：

TISSUE ANTIGENS | 1997年 / 49卷 / 05期

关键词：

insulin-dependent diabetes mellitus; HLA-DR4; haplotype; HLA-DQB1*0304;

D O I：

10.1111/j.1399-0039.1997.tb02794.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The rare HLA-DQB1*0304 allele was found increased among IDDM patients in the populations of the eastern Baltic region. Its frequency among IDDM patients was 4.5% (20/443) compared to 1.1% (9/853) in healthy controls in the combined series of Estonian, Latvian and St. Petersburg Russian populations (P=0.0001). HLA-DQB1*0304 in these populations was associated with DRB1*0408, and the haplotype was further characterized by a B35 allele and a typical combination of microsatellite markers from the TNF gene region. The result is compatible with the significance of the 57th amino acid in the DQ beta-chain but also emphasizes the importance of alleles in other HLA loci adjacent to DQ in the determination of IDDM susceptibility.

引用

页码：532 / 534

页数：3

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HLA-DQB1*0304-DRB1*0408 haplotype associated with insulin-dependent diabetes mellitus in populations in the eastern Baltic region

HLA-DQB10304-DRB10408 haplotype associated with insulin-dependent diabetes mellitus in populations in the eastern Baltic region