The natural history of HIV-1 infection in young Thai men after seroconversion

被引:48
作者
Rangsin, R
Chiu, J
Khamboonruang, C
Sirisopana, N
Eiumtrakul, S
Brown, AE
Robb, M
Beyrer, C
Ruangyuttikarn, C
Markowitz, LE
Nelson, KE
机构
[1] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA
[2] Phramongkutklao Coll Med, Dept Mil & Community Med, Bangkok, Thailand
[3] Henry M Jackson Fdn, Rockville, MD USA
[4] Henry M Jackson Fdn, Bangkok, Thailand
[5] Chiang Mai Univ, Res Inst Hlth Sci, Chiang Mai 50000, Thailand
[6] Armed Forces Res Inst Med Sci, Bangkok, Thailand
[7] Royal Thai Army, Army Inst Pathol, Bangkok, Thailand
关键词
HIV infection progression; Thailand; natural history of HIV-1; HIV-1 subtype E (CRF01_AE); HIV-1 infection survival;
D O I
10.1097/00126334-200405010-00011
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The natural history and progression of HIV-1 infection in Thailand and other developing countries in Asia and Africa have not been well defined. Nevertheless, valid data are needed to evaluate the effects of interventions, which are designed to delay progression. We evaluated the progression to AIDS and death in 235 men who seroconverted during their 2 years of service in the Royal Thai Army. The men were conscripted at age 21 and seroconverted within a 6-month window during follow-up while in the military. The seroconverters were matched with men who were seronegative when discharged. Of the HIV-positive men, 156 (66.4%) were alive, 77 (32.8%) had died, and 2 (0.8%) could not be located 5-7 years after their seroconversion and discharge from the military. The 5-year survival rate was 82.3%; the median times to clinical AIDS and a CD4(+) cell count of <200/muL was 7.4 years and 6.9 years, respectively. The mortality rate was 56.3 deaths per 1000 patient-years for HIV-positive men and 6.1 deaths per 1000 patient-years for HIV-negative men. Our data suggest a more rapid progression to AIDS and death after HIV-1 infection in young men in Thailand than has been reported for similarly aged cohorts in developed countries.
引用
收藏
页码:622 / 629
页数:8
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