Magnetic resonance imaging of atherosclerotic plaques using superparamagnetic iron oxide particles

被引:148
作者
Schmitz, SA [1 ]
Taupitz, M [1 ]
Wagner, S [1 ]
Wolf, KJ [1 ]
Beyersdorff, D [1 ]
Hamm, B [1 ]
机构
[1] Humboldt Univ, Inst Radiol, Charite, D-10098 Berlin, Germany
关键词
atherosclerosis; inflammatory atherosclerotic lesions; magnetic resonance imaging; plaque inflammation; superparamagneticm iron oxide (SPIO);
D O I
10.1002/jmri.1194
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Experimental data show accumulation of superparamagnetic iron oxide (SPIO) particles in atherosclerotic plaques. SPIO uptake occurred In plaques, suggesting an increased endothelial permeability and macrophage infiltrates as signs of inflammatory plaque activity. We incidentally observed SPIO uptake in aortic and arterial wall segments in patients who had originally received the magnetic resonance (MR) contrast agent for staging lymph node metastases. Twenty patients (19 male, 1 female; mean age, 64; range, 41-78 years) with bladder or prostate cancer underwent MR imaging (MRI) using a T2*-weighted high-resolution gradient-echo sequence prior to and 24-36 hours after intravenous injection of 2.6 mg of Fe/kg of SPIO (Sinerem(R)). The aorta, both common external and internal iliac, as well as both superficial femoral arteries, were retrospectively analyzed for atherosclerotic wall changes. One patient was excluded. A positive finding was defined as an area of pronounced signal loss on postcontrast images clearly confined to the arterial wall, which was absent in the precontrast examination or increased in size. Such a finding was observed in one to three arteries in 7 of the 19 patients. The pronounced signal loss in the wall of the aorta and pelvic arteries seen in part of an elderly patient population after intravenous SPIO administration strongly suggests that this contrast agent accumulates in human atherosclerotic plaques. J. Magn. Reson. Imaging 200 1; 14: 355-361. (C) 2001 Wiley-Liss, Inc.
引用
收藏
页码:355 / 361
页数:7
相关论文
共 16 条
[1]  
Boyle JJ, 1997, J PATHOL, V181, P93, DOI 10.1002/(SICI)1096-9896(199701)181:1<93::AID-PATH696>3.0.CO
[2]  
2-H
[3]   SUPERPARAMAGNETIC IRON-OXIDES AS POSITIVE MR CONTRAST AGENTS - INVITRO AND INVIVO EVIDENCE [J].
CHAMBON, C ;
CLEMENT, O ;
LEBLANCHE, A ;
SCHOUMANCLAEYS, E ;
FRIJA, G .
MAGNETIC RESONANCE IMAGING, 1993, 11 (04) :509-519
[4]   Intravascular magnetic resonance imaging of aortic atherosclerotic plaque composition [J].
Correia, LCL ;
Atalar, E ;
Kelemen, MD ;
Ocali, O ;
Hutchins, GM ;
Fleg, JL ;
Gerstenblith, G ;
Zerhouni, EA ;
Lima, JAC .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1997, 17 (12) :3626-3632
[5]  
Daldrup HE, 1999, JMRI-J MAGN RESON IM, V9, P643, DOI 10.1002/(SICI)1522-2586(199905)9:5<643::AID-JMRI5>3.0.CO
[6]  
2-A
[7]  
DAVIES MJ, 1993, BRIT HEART J, V69, P377
[8]  
Fuster V, 1999, AM HEART MONOGR S, P393
[9]   PHASE-I CLINICAL-EVALUATION OF A NEW IRON-OXIDE MR CONTRAST AGENT [J].
MCLACHLAN, SJ ;
MORRIS, MR ;
LUCAS, MA ;
FISCO, RA ;
EAKINS, MN ;
FOWLER, DR ;
SCHEETZ, RB ;
OLUKOTUN, AY .
JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING, 1994, 4 (03) :301-307
[10]   INTRAVASCULAR ULTRASOUND IMAGING - INVITRO VALIDATION AND PATHOLOGICAL CORRELATION [J].
NISHIMURA, RA ;
EDWARDS, WD ;
WARNES, CA ;
REEDER, GS ;
HOLMES, DR ;
TAJIK, AJ ;
YOCK, PG .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1990, 16 (01) :145-154