Hyperprolactinemia-induced ovarian acyclicity is reversed by kisspeptin administration

被引：130

作者：

Sonigo, Charlotte ^{[1
]}

Bouilly, Justine ^{[1
]}

Carre, Nadege ^{[1
]}

Tolle, Virginie ^{[2
]}

Caraty, Alain ^{[3
]}

Tello, Javier ^{[4
]}

Simony-Conesa, Fabian-Jesus ^{[4
]}

Millar, Robert ^{[4
,5
,6
]}

Young, Jacques ^{[1
,7
]}

Binart, Nadine ^{[1
,7
]}

机构：

[1] Univ Paris Sud, INSERM, U693, Fac Med Paris Sud, F-94276 Le Kremlin Bicetre, France

[2] Univ Paris Descartes Sorbonne Paris, INSERM, U894, Ctr Psychiat & Neurosci, Paris, France

[3] Univ Tours, INRA, CNRS, UMR 6175, Nouzilly, France

[4] Univ Edinburgh, Ctr Integrat Physiol, Edinburgh, Midlothian, Scotland

[5] Univ Pretoria, Mammal Res Inst, ZA-0002 Pretoria, South Africa

[6] Univ Cape Town, UCT MRC Receptor Biol Unit, ZA-7925 Cape Town, South Africa

[7] Hop Bicetre, AP HP, Serv Endocrinol & Malad Reprod, Le Kremlin Bicetre, France

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2012年 / 122卷 / 10期

基金：

英国医学研究理事会;

关键词：

GONADOTROPIN-RELEASING-HORMONE; LACTATION; SECRETION; INSULIN; CELLS;

D O I：

10.1172/JCI63937

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Hyperprolactinemia is the most common cause of hypogonadotropic anovulation and is one of the leading causes of infertility in women aged 25-34. Hyperprolactinemia has been proposed to block ovulation through inhibition of GnRH release. Kisspeptin neurons, which express prolactin receptors, were recently identified as major regulators of GnRH neurons. To mimic the human pathology of anovulation, we continuously infused female mice with prolactin. Our studies demonstrated that hyperprolactinemia in mice induced anovulation, reduced GnRH and gonadotropin secretion, and diminished kisspeptin expression. Kisspeptin administration restored gonadotropin secretion and ovarian cyclicity, suggesting that kisspeptin neurons play a major role in hyperprolactinemic anovulation. Our studies indicate that administration of kisspeptin may serve as an alternative therapeutic approach to restore the fertility of hyperprolactinemic women who are resistant or intolerant to dopamine agonists.

引用

页码：3791 / 3795

页数：5

共 23 条

[1]

GONADOTROPIN-RELEASING HORMONE PULSATILE ADMINISTRATION RESTORES LUTEINIZING-HORMONE PULSATILITY AND NORMAL TESTOSTERONE LEVELS IN MALES WITH HYPERPROLACTINEMIA [J].