Noncoding RNAs in Long-Term Memory Formation

被引:96
作者
Mercer, Tim R. [1 ]
Dinger, Marcel E. [1 ]
Mariani, Jean [2 ]
Kosik, Kenneth S. [3 ]
Mehler, Mark F. [4 ,5 ,6 ,7 ]
Mattick, John S. [1 ]
机构
[1] Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia
[2] Univ Paris 06, UMR 7102, CNRS, F-75252 Paris 05, France
[3] Univ Calif Santa Barbara, Neurosci Res Inst, Santa Barbara, CA 93106 USA
[4] Albert Einstein Coll Med, Inst Brain Disorders & Neural Regenerat, Dept Neurol, Bronx, NY 10467 USA
[5] Albert Einstein Coll Med, Inst Brain Disorders & Neural Regenerat, Dept Neurosci & Psychiat, Bronx, NY 10467 USA
[6] Albert Einstein Coll Med, Inst Brain Disorders & Neural Regenerat, Dept Behav Sci, Bronx, NY 10467 USA
[7] Albert Einstein Coll Med, Rose F Kennedy Ctr Res Mental Retardat & Dev Disa, Bronx, NY 10467 USA
基金
澳大利亚研究理事会;
关键词
long-term potentiation; synaptic plasticity; microRNAs; neuron; intercellular signaling;
D O I
10.1177/1073858408319187
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Current research exploring the molecular basis of memory focuses mainly on proteins despite recent genomic studies reporting the abundant transcription of non-protein-coding RNA (ncRNA). Although ncRNAs are involved in a diverse range of biological processes, they are particularly prevalent within the nervous system, where they contribute towards the complexity and function of the mammalian brain. In this review, we apply recent advances in ncRNA biology to predict a critical role for ncRNAs in the molecular mechanisms underlying memory formation and maintenance. We describe the role of ncRNAs in regulating the translation, stability, and editing of mRNA populations in response to synaptic activity during memory formation and the role of ncRNAs in the epigenetic and transcriptional programs that underlie long-term memory storage. We also consider ncRNAs acting as an additional avenue of communication between neurons by their intercellular trafficking. Taken together, the emerging evidence suggests a central role for ncRNAs in memory formation and provokes novel research directions in this field. NEUROSCIENTIST 14(5):434-445, 2008. DOI: 10.1177/1073858408319187
引用
收藏
页码:434 / 445
页数:12
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