Photosensitizers in clinical PDT

被引：839

作者：

Allison, Ron R. ^{[1
,2
]}

Downie, Gordon H. ^{[2
,3
]}

Cuenca, Rosa ^{[2
,4
]}

Hu, Xin-Hua ^{[1
,2
,5
]}

Childs, Carter J. H. ^{[2
,3
]}

Sibata, Claudio H. ^{[1
,2
,5
]}

机构：

[1] E Carolina Univ, Brody Sch Med, Dept Radiat Oncol, Greenville, NC 27858 USA

[2] E Carolina Univ, Brody Sch Med, Leo Jenkins Canc Ctr, PDT Ctr, Greenville, NC 27858 USA

[3] E Carolina Univ, Brody Sch Med, Dept Med Pulm & Crit Care Med, Greenville, NC 27858 USA

[4] E Carolina Univ, Brody Sch Med, Dept Surg Oncol, Greenville, NC 27858 USA

[5] E Carolina Univ, Dept Phys, Greenville, NC 27858 USA

来源：

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY | 2004年 / 1卷 / 01期

关键词：

Photosensitizers; Photodynamic therapy; Review;

D O I：

10.1016/S1572-1000(04)00007-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Photosensitizers in photodynamic therapy allow for the transfer and translation of light energy into a type II chemical reaction. In clinical practice, photosensitizers arise from three families-porphyrins, chlorophylls, and dyes. All clinically successful photosensitizers have the ability to a greater or lesser degree, to target specific tissues or their vasculature to achieve ablation. Each photosensitizer needs to reliably activate at a high enough light wavelength useful for therapy. Their ability to fluoresce and visualize the lesion is a bonus. Photosensitizers developed from each family have unique properties that have so far been minimally clinically exploited. This review looks at the potential benefits and consequences of each major photosensitizer that has been tried in a clinical setting. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：27 / 42

页数：16

共 155 条

[11] COMBINED ACTION OF PHTHALOCYANINE PHOTOSENSITIZATION AND GAMMA-RADIATION ON MAMMALIAN-CELLS [J].