Subversion of immune cell signal transduction pathways by the secreted filarial nematode product, ES-62

被引：19

作者：

Harnett, W ^{[1
]}

Goodridge, HS

Harnett, MM

机构：

[1] Univ Strathclyde, Dept Immunol, Glasgow G4 0NR, Lanark, Scotland

[2] Univ Glasgow, Div Immunol Infect & Inflammat, Glasgow G11 6NT, Lanark, Scotland

来源：

PARASITOLOGY | 2005年 / 130卷

基金：

英国惠康基金;

关键词：

ES-62; filarial nematode; immune system cells; signal transduction;

D O I：

10.1017/S0031182005008164

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Filarial nematodes achieve longevity within the infected host by Suppressing and modulating the host immune response. To do this, the worms actively secrete products that have been demonstrated to Possess immunomodulatory properties. In this article we discuss the immunomodulatory, effects of the phosphorylcholine-containing filarial nematode secreted glycoprotein ES-62. In particular we describe how it modulates intracellular signal transduction pathways in a number of different cells of the immune system, in particular B-lymphocytes, T-lymphocytes, macrophages and dendritic cells.

引用

页码：S63 / S68

页数：6

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