Synthesis of novel proline and γ-lactam derivatives as non-peptide mimics of Somatostatin/Sandostatin®

被引:22
作者
Damour, D [1 ]
Herman, F [1 ]
Labaudinière, R [1 ]
Pantel, G [1 ]
Vuilhorgne, M [1 ]
Mignani, S [1 ]
机构
[1] Rhone Poulenc Rorer SA, Ctr Rech Vitry Alfortville, F-94403 Vitry, France
关键词
D O I
10.1016/S0040-4020(99)00561-X
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Original proline or gamma-lactam derivatives bearing either an aryl group such as a phenyl or a 3-indolyl in position 3 of the proline moiety or on the 3-methyl chain of the gamma-lactam skeleton were prepared as nonpeptide mimics of Somatostatin/Sandostatin(R). (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:10135 / 10154
页数:20
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