Regulation of nuclear Ca2+ signaling by translocation of the Ca2+ messenger synthesizing enzyme ADP-ribosyl cyclase during neuronal depolarization

被引:40
作者
Bezin, Stephanie [1 ]
Charpentier, Gilles [1 ,2 ]
Lee, Hon Cheung [3 ]
Baux, Gerard [1 ]
Fossier, Philippe [1 ]
Cancela, Jose-Manuel [1 ]
机构
[1] CNRS, Neurobiol Cellulaire & Mol Lab, UPR 9040, F-91198 Gif Sur Yvette, France
[2] Univ Bordeaux 1, Lab DMPFCS, IECB, F-33607 Pessac, France
[3] Univ Hong Kong, Dept Physiol, Hong Kong, Hong Kong, Peoples R China
关键词
D O I
10.1074/jbc.M804701200
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In neurons, voltage-gated Ca2+ channels and nuclear Ca2+ signaling play important roles, such as in the regulation of gene expression. However, the link between electrical activity and biochemical cascade activation involved in the generation of the nuclear Ca2+ signaling is poorly understood. Here we show that depolarization of Aplysia neurons induces the translocation of ADP-ribosyl cyclase, a Ca2+ messenger synthesizing enzyme, from the cytosol into the nucleus. The translocation is dependent on Ca2+ influx mainly through the voltage-dependent L-type Ca2+ channels. We report also that specific nucleoplasmic Ca2+ signals can be induced by three different calcium messengers, cyclic ADP-ribose, nicotinic acid adenine dinucleotide phosphate (NAADP), both produced by the ADP-ribosyl cyclase, and inositol 1,4,5-trisphosphate (IP3). Moreover, our pharmacological data show that NAADP acts on its own receptor, which cooperates with the IP3 and the ryanodine receptors to generate nucleoplasmic Ca2+ oscillations. We propose a new model where voltage-dependent L-type Ca2+ channel-induced nuclear translocation of the cytosolic cyclase is a crucial step in the fine tuning of nuclear Ca2+ signals in neurons.
引用
收藏
页码:27859 / 27870
页数:12
相关论文
共 80 条
  • [41] The C terminus of the L-type voltage-gated calcium channel Cav1.2 encodes a transcription factor
    Gomez-Ospina, Natalia
    Tsuruta, Fuminori
    Barreto-Chang, Odmara
    Hu, Linda
    Dolmetsch, Ricardo
    [J]. CELL, 2006, 127 (03) : 591 - 606
  • [42] Molecular mechanisms of memory storage in Aplysia
    Hawkins, Robert D.
    Kandel, Eric R.
    Bailey, Craig H.
    [J]. BIOLOGICAL BULLETIN, 2006, 210 (03) : 174 - 191
  • [43] PURIFICATION AND CHARACTERIZATION OF A MOLLUSCAN EGG-SPECIFIC NADASE, A 2ND-MESSENGER ENZYME
    HELLMICH, MR
    STRUMWASSER, F
    [J]. CELL REGULATION, 1991, 2 (03): : 193 - 202
  • [44] Transcriptional control of cognitive development
    Hong, EJ
    West, AE
    Greenberg, ME
    [J]. CURRENT OPINION IN NEUROBIOLOGY, 2005, 15 (01) : 21 - 28
  • [45] FORMATION AND HYDROLYSIS OF CYCLIC ADP RIBOSE CATALYZED BY LYMPHOCYTE ANTIGEN-CD38
    HOWARD, M
    GRIMALDI, JC
    BAZAN, JF
    LUND, FE
    SANTOSARGUMEDO, L
    PARKHOUSE, RME
    WALSETH, TF
    LEE, HC
    [J]. SCIENCE, 1993, 262 (5136) : 1056 - 1059
  • [46] Jin I, 2003, J NEUROSCI, V23, P7288
  • [47] Functional metabotropic glutamate receptors on nuclei from brain and primary cultured striatal neurons - Role of transporters in delivering ligand
    Jong, YJI
    Kumar, V
    Kingston, AE
    Romano, C
    O'Malley, KL
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (34) : 30469 - 30480
  • [48] Localization of the cyclic ADP-ribose-dependent calcium signaling pathway in hepatocyte nucleus
    Khoo, KM
    Han, MK
    Park, JB
    Chae, SW
    Kim, UH
    Lee, HC
    Bay, BH
    Chang, CF
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (32) : 24807 - 24817
  • [49] Twenty years of calcium imaging: Cell physiology to dye for
    Knot, HJ
    Laher, I
    Sobie, EA
    Guatimosim, S
    Gomez-Viquez, L
    Hartmann, H
    Song, LS
    Lederer, WJ
    Graier, WF
    Malli, R
    Frieden, M
    Petersen, OH
    [J]. MOLECULAR INTERVENTIONS, 2005, 5 (02) : 112 - 127
  • [50] Ca2+ release via ryanodine receptors and Ca2+ entry:: major mechanisms in NAADP-mediated Ca2+ signaling in T-lymphocytes
    Langhorst, MF
    Schwarzmann, N
    Guse, AH
    [J]. CELLULAR SIGNALLING, 2004, 16 (11) : 1283 - 1289