A novel K+ channel blocking toxin from Tityus discrepans scorpion venom

被引：26

作者：

D'Suze, G

Zamudio, F

Gómez-Lagunas, F

Possani, LD

机构：

[1] Inst Venezolano Invest Cient, Lab Cellular Neuropharmacol, Biochem & Biophys Ctr, Caracas 1020A, Venezuela

[2] Natl Autonomous Univ Mexico, Dept Mol Recognit & Struct Biol, Inst Biotechnol, Cuernavaca 62210, Morelos, Mexico

来源：

FEBS LETTERS | 1999年 / 456卷 / 01期

关键词：

amino acid sequence; K+ channel; shakerB; scorpion venom; Tityus discrepans;

D O I：

10.1016/S0014-5793(99)00947-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel toxin (TdK1) was purified from the venom of the scorpion Tityus discrepans, sequenced and functionally characterized, It contains 37 amino acid residues and blocks reversible the shakerB K+ channel expressed in SF9 cells with a K-d in the order of 280 nM, The proposed systematic nomenclature for this peptide is alpha-KTx4.3. (C) 1999 Federation of European Biochemical Societies.

引用

页码：146 / 148

页数：3

共 13 条

[1] PRESENCE OF CURARIZING POLYPEPTIDES AND A PANCREATITIS-INDUCING FRACTION WITHOUT MUSCARINIC EFFECTS IN THE VENOM OF THE VENEZUELAN SCORPION TITYUS DISCREPANS (KARSCH) [J].