Drug-eluting stent-supported percutaneous coronary intervention for chronic total coronary occlusion

Objectives: This study sought to determine the clinical and angiographic outcomes after drug-eluting stent (DES)-supported percutaneous coronary intervention (PCI) for chronic total coronary occlusion (CTO). Background: There are few data about the efficacy of DES-supported PCI for CTO. Methods: All consecutive patients who had a sirolimuseluting stent or a paclitaxel-eluting stent implanted for CTO from December 2003 to December 2004 were analyzed. Clinical and angiographic outcomes of patients treated with DES were compared with a case-matched control group of patients treated with bare metal stents (BMS) in the 12 months before the routine use of DES. Results: Successful DES-supported PCI was performed in 92 patients and 104 CTO. The case-matched control group consisted of 26 patients and 27 CTO successfully treated with BMS. There were no differences between groups in baseline clinical and angiographic characteristics. Stent length in the DES group was higher as compared with that of BMS group (51 +/- 28 mill vs. 40 +/- 19 mm, P = 0.073). The 6-month major adverse cardiac event (MACE) rate was lower in the DES group as compared with that of BMS group (9.8% vs. 23%, P = 0.072). The angiographic follow-rate was 80% in the DES group and 81% in the BMS group. The 6-month restenosis rate was 19% in the DES group and 45% in the BMS group (P < 0.001). By multivariate analysis, it was found that in the DES group, the only predictors of restenosis were stented segment length (OR 1.031, 95% Cl 1.01-1.06, P = 0.009) and a target vessel reference diameter < 2.5 mm (OR 6.48, 95% Cl 1.51-27.83, P = 0.012), while the only predictor of MACE was stent length (OR 1.04, 95% Cl 1.01-1.08, P = 0.006). Conclusions: DES implantation for CTO decreases the risk of mid-term A restenosis and MACE. Small vessels and diffuse disease requiring the implantation of multiple stents and very long stents for full coverage of the target lesion are still associated with a relatively high risk of restenosis. (c) 2006 Wiley-Liss, Inc.