Apolipoprotein Concentrations Are Elevated in Malignant Ovarian Cyst Fluids Suggesting That Lipoprotein Metabolism Is Dysregulated in Epithelial Ovarian Cancer

被引：26

作者：

Podzielinski, Iwona ^{[1
]}

Saunders, Brook A. ^{[2
]}

Kimbler, Kimberly D. ^{[3
]}

Branscum, Adam J. ^{[4
]}

Fung, Eric T. ^{[5
]}

DePriest, Paul D. ^{[6
]}

van Nagell, John R. ^{[6
]}

Ueland, Frederick R. ^{[6
]}

Baron, Andre T. ^{[6
,7
]}

机构：

[1] Ft Wayne Gynecol Oncol Ctr, Ft Wayne, IN USA

[2] Knoxville Gynecol Canc Specialists, Knoxville, TN USA

[3] Univ Kentucky, Kentucky Canc Registry, Lexington, KY 40536 USA

[4] Oregon State Univ, Coll Publ Hlth & Human Sci, Biostat Program, Corvallis, OR 97331 USA

[5] Vermillion Inc, Austin, TX USA

[6] Univ Kentucky, Dept Obstet & Gynecol, Div Gynecol Oncol, Lucille P Markey Canc Ctr, Lexington, KY 40536 USA

[7] Univ Kentucky, Dept Epidemiol, Coll Publ Hlth, Lexington, KY 40536 USA

来源：

CANCER INVESTIGATION | 2013年 / 31卷 / 04期

关键词：

Cancer biomarkers; Detection/diagnosis; Ovarian cancer; Protein profiling; Tumor biology; ENDOTHELIAL GROWTH-FACTOR; LOW-DENSITY-LIPOPROTEIN; NECROSIS-FACTOR-ALPHA; A-II; CHOLESTEROL ACYLTRANSFERASE; MATRIX METALLOPROTEINASES; BINDING PROTEIN-2; SOLUBLE RECEPTOR; GENE-EXPRESSION; TUMOR-MARKERS;

D O I：

10.3109/07357907.2013.789896

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

SELDI-TOF MS analysis of ovarian cyst fluids revealed that peaks m/z 8696 and 8825 discriminate malignant, borderline, and benign tumors. These peaks correspond to isoforms of apoA2. ELISA demonstrates that apoA1, A2, B, C2, C3, and E cyst fluid concentrations are uncorrelated and higher in malignant ovarian tumors, but only apoA2, apoE, and age are independent classifiers of malignant ovarian tumors, yielding 55.1% sensitivity, 95% specificity, and 88.1% accuracy to discern malignant from benign and borderline tumors. These data suggest that lipoprotein metabolism is dysregulated in ovarian cancer and that apoA2 and apoE warrant further investigation as ovarian tumor biomarkers.

引用

页码：258 / 272

页数：15

共 134 条

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