Biochemical evidence that Patched is the Hedgehog receptor

被引：707

作者：

Marigo, V

Davey, RA

Zuo, Y

Cunningham, JM

Tabin, CJ

机构：

[1] HARVARD UNIV, SCH MED, DEPT GENET, BOSTON, MA 02115 USA

[2] BRIGHAM & WOMENS HOSP, HOWARD HUGHES MED INST, BOSTON, MA 02115 USA

来源：

NATURE | 1996年 / 384卷 / 6605期

关键词：

D O I：

10.1038/384176a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

THE protein Sonic hedgehog (Shh) is essential for a variety of patterning events during development. It is the signal from the notochord that induces ventral cell fate in the neural tube and somites(1,2), and is the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud(3). Because of these and other inductive functions of Shh, it is important to understand how the Hedgehog (Hh) signal is received by the target cells. Here we describe binding studies using labelled Shh that strongly suggest that the Hh receptor is encoded by patched (ptc), a gene first identified in genetic screens in Drosophila(4).

引用

页码：176 / 179

页数：4

共 29 条

[11] A POTENTIAL CATALYTIC SITE REVEALED BY THE 1.7-ANGSTROM CRYSTAL-STRUCTURE OF THE AMINO-TERMINAL SIGNALING DOMAIN OF SONIC HEDGEHOG
HALL, TMT
PORTER, JA
BEACHY, PA
LEAHY, DJ
[J]. NATURE, 1995, 378 (6553) : 212 - 216
[12] HIDALGO A, 1990, DEVELOPMENT, V110, P291
[13] THE DROSOPHILA PATCHED GENE ENCODES A PUTATIVE MEMBRANE-PROTEIN REQUIRED FOR SEGMENTAL PATTERNING
HOOPER, JE
SCOTT, MP
[J]. CELL, 1989, 59 (04) : 751 - 765
[14] DISTINCT PATHWAYS FOR AUTOCRINE AND PARACRINE WINGLESS SIGNALING IN DROSOPHILA EMBRYOS
HOOPER, JE
[J]. NATURE, 1994, 372 (6505) : 461 - 464
[15] ROLE OF THE DROSOPHILA PATCHED GENE IN POSITIONAL SIGNALING
INGHAM, PW
TAYLOR, AM
NAKANO, Y
[J]. NATURE, 1991, 353 (6340) : 184 - 187
[16] LIMB-PATTERNING ACTIVITY AND RESTRICTED POSTERIOR LOCALIZATION OF THE AMINO-TERMINAL PRODUCT OF SONIC HEDGEHOG CLEAVAGE
LOPEZMARTINEZ, A
CHANG, DT
CHIANG, C
PORTER, JA
ROS, MA
SIMANDL, BK
BEACHY, PA
FALLON, JF
[J]. CURRENT BIOLOGY, 1995, 5 (07) : 791 - 796
[17] Neural patterning: A forward role for hedgehog
Lumsden, A
Graham, A
[J]. CURRENT BIOLOGY, 1995, 5 (12) : 1347 - 1350
[18] Marigo V, 1996, DEVELOPMENT, V122, P1225
[19] REQUIREMENT OF 19K FORM OF SONIC HEDGEHOG FOR INDUCTION OF DISTINCT VENTRAL CELL-TYPES IN CNS EXPLANTS
MARTI, E
BUMCROT, DA
TAKADA, R
MCMAHON, AP
[J]. NATURE, 1995, 375 (6529) : 322 - 325
[20] COMBINATORIAL SIGNALING BY SONIC HEDGEHOG AND WNT FAMILY MEMBERS INDUCES MYOGENIC BHLH GENE-EXPRESSION IN THE SOMITE
MUNSTERBERG, AE
KITAJEWSKI, J
BUMCROT, DA
MCMAHON, AP
LASSAR, AB
[J]. GENES & DEVELOPMENT, 1995, 9 (23) : 2911 - 2922

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