Programming off and on states in chromatin: mechanisms of Polycomb and trithorax group complexes

被引：285

作者：

Simon, JA

Tamkun, JW

机构：

[1] Univ Minnesota, Dept Genet Cell Biol & Dev, Minneapolis, MN 55455 USA

[2] Univ Calif Santa Cruz, Dept Mol Cell & Dev Biol, Sinsheimer Labs 350, Santa Cruz, CA 95064 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2002年 / 12卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0959-437X(02)00288-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Polycomb and trithorax group proteins are evolutionarily conserved chromatin components that maintain stable states of gene expression. Recent studies have identified and characterized several multiprotein complexes containing these transcriptional regulators. Advances in understanding molecular activities of these complexes in vitro, and functional domains present in their subunits, suggest that they control transcription through multistep mechanisms that involve nucleosome modification, chromatin remodeling, and interaction with general transcription factors.

引用

收藏

页码：210 / 218

页数：9

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