Very small size proteoliposomes derived from Neisseria meningitidis:: An effective adjuvant for generation of CTL responses to peptide and protein antigens

被引：34

作者：

Mesa, C ^{[1
]}

de León, J ^{[1
]}

Fernández, LE ^{[1
]}

机构：

[1] Ctr Mol Immunol, Vaccines Dept, C Habanna 16040, Cuba

来源：

VACCINE | 2006年 / 24卷 / 14期

关键词：

CTL; cross-priming; Neisseria meningitidis;

D O I：

10.1016/j.vaccine.2005.08.111

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The development of potent adjuvants, conditioning innate and adaptative immunity, particularly CTL responses, has become currently a hot point in the rational design of vaccines for cancer immunotherapy. We have described a new approach, in which gangliosides are incorporated into vesicles from Neisseria meningitidis to form Very Small Size Proteoliposomes (VSSP). VSSP is a good alternative to the existing adjuvants for use in whole cells vaccines since it promotes 80% tumour rejection and growing delay in the CT26 and F3II tumour models respectively. Also VSSP induces activation of CTL responses to co-injected trimmed peptides and soluble proteins. This phenomena is facilitated by the cross-presentation of exogenous antigen and do not need cooperation of CD4 T cells for primary CD8 T cells expansion. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：2692 / 2699

页数：8

共 44 条

[1] Dendritic cells acquire antigen from apoptotic cells and induce class I restricted CTLs [J].