Activins in adipogenesis and obesity

被引：38

作者：

Dani, C. ^{[1
]}

机构：

[1] Univ Nice Sophia Antipolis, CNRS Inserm, Fac Med, Inst Biol Valrose, F-06107 Nice 2, France

来源：

INTERNATIONAL JOURNAL OF OBESITY | 2013年 / 37卷 / 02期

关键词：

activin; adipocyte progenitors; adipocytes; HUMAN ADIPOSE PROGENITORS; INHIBIN BETA-B; FAT MASS; PREADIPOCYTE DIFFERENTIATION; CELL-PROLIFERATION; METABOLIC DISEASE; BINDING-PROTEIN; GROWTH-FACTORS; TISSUE; EXPRESSION;

D O I：

10.1038/ijo.2012.28

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Activins are secreted proteins members of the transforming growth factor-beta family. They are involved in many biological responses including regulation of apoptosis, proliferation and differentiation of different cell types. Activins A, B and AB are highly expressed in adipose tissue, and in this review we will illustrate that activins have a role in several steps of physiological and pathological development of adipose tissue. Activin A has been shown to be a critical regulator of human adipocyte progenitor proliferation and a potent inhibitor of their differentiation. Activin A could also be a mediator of fibrosis observed in obese adipose tissue. Activin B/AB is proposed as a new adipokine having a role in energy balance and insulin insensitivity associated with obesity. Therefore, activin pathway could represent a potential therapeutic target both for controlling the size and the phenotype of the adipose precursor pool and for obesity-associated metabolic complications. International Journal of Obesity (2013) 37, 163-166; doi:10.1038/ijo.2012.28; published online 28 February 2012

引用

页码：163 / 166

页数：4

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