Current advances in molecular imaging of gene and cell therapy for cancer

被引：20

作者：

Shah, K ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Ctr Mol Imaging, Cambridge, MA 02138 USA

[2] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Neurol, Cambridge, MA 02138 USA

来源：

CANCER BIOLOGY & THERAPY | 2005年 / 4卷 / 05期

关键词：

virus vectors; bioluminescence; fluorescence; gene therapy; neural stem cells; tumors;

D O I：

10.4161/cbt.4.5.1706

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

For ensuring success of gene and cell based therapies it is of prime importance to develop technology for non-invasive monitoring of the location and duration of gene expression, distribution and targeting of therapeutically engineered cells and vector particles in vivo. A number of advances have been achieved in high resolution, in vivo imaging methods, such as bioluminescence imaging, Magnetic resonance imaging (MRI), positron emission tomography (PET) and various fluorescence imaging techniques, including fluorescence mediated tomography (FMT) and near infrared fluorescence (NIRF) reflectance imaging. In this review we will discuss different imaging modalities that have found applications in gene and cell therapies of cancer.

引用

页码：518 / 523

页数：6

共 60 条

[1] Noninvasive MR imaging of magnetically labeled stem cells to directly identify neovasculature in a glioma model [J].

Anderson, SA ;

Glod, J ;

Arbab, AS ;

Noel, M ;

Ashari, P ;

Fine, HA ;

Frank, JA .

BLOOD, 2005, 105 (01) :420-425

[2] Receptor-targeted optical imaging of tumors with near-infrared fluorescent ligands [J].

Becker, A ;

Hessenius, C ;

Licha, K ;

Ebert, B ;

Sukowski, U ;

Semmler, W ;

Wiedenmann, B ;

Grötzinger, C .

NATURE BIOTECHNOLOGY, 2001, 19 (04) :327-331

[3]

Blackstock AW, 2001, CLIN CANCER RES, V7, P3263

[4]

Blasberg RG, 1999, Q J NUCL MED, V43, P163

[5] The development of in vivo imaging systems to study gene expression [J].

Bogdanov, A ;

Weissleder, R .

TRENDS IN BIOTECHNOLOGY, 1998, 16 (01) :5-10

[6] Determination of chemotherapeutic activity in vivo by luminescent imaging of luciferase-transfected human tumors [J].

Caceres, G ;

Zankina, R ;

Zhu, XY ;

Jiao, JA ;

Wong, H ;

Aller, A ;

Andreotti, P .

ANTI-CANCER DRUGS, 2003, 14 (07) :569-574

[7] A phase I open-label, dose-escalation, multi-institutional trial of injection with an E1B-attenuated adenovirus, ONYX-015, into the peritumoral region of recurrent malignant gliomas, in the adjuvant setting [J].

Chiocca, EA ;

Abbed, KM ;

Tatter, S ;

Louis, DN ;

Hochberg, FH ;

Barker, F ;

Kracher, J ;

Grossman, SA ;

Fisher, JD ;

Carson, K ;

Rosenblum, M ;

Mikkelsen, T ;

Olson, J ;

Markert, J ;

Rosenfeld, S ;

Nabors, LB ;

Brem, S ;

Phuphanich, S ;

Freeman, S ;

Kaplan, R ;

Zwiebel, J .

MOLECULAR THERAPY, 2004, 10 (05) :958-966

[8] Use of reporter genes for optical measurements of neoplastic disease in vivo [J].

Contag, CH ;

Jenkins, D ;

Contag, FR ;

Negrin, RS .

NEOPLASIA, 2000, 2 (1-2) :41-52

[9] Spontaneous and controllable activation of suicide gene expression driven by the stress-inducible Grp78 promoter resulting in eradication of sizable human tumors [J].

Dong, DZ ;

Dubeau, L ;

Bading, J ;

Nguyen, K ;

Luna, M ;

Yu, H ;

Gazit-Bornstein, G ;

Gordon, EM ;

Gomer, C ;

Hall, FL ;

Gambhir, SS ;

Lee, AS .

HUMAN GENE THERAPY, 2004, 15 (06) :553-561

[10] Quantitative imaging of the T cell antitumor response by positron-emission tomography [J].

Dubey, P ;

Su, H ;

Adonai, N ;

Du, SY ;

Rosato, A ;

Braun, J ;

Gambhir, SS ;

Witte, ON .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (03) :1232-1237

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