A conserved rnRNA export machinery coupled to pre-mRNA splicing

被引：315

作者：

Reed, R

Hurt, E ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

[2] Heidelberg Univ, Biochem Zentrum Heidelberg, D-69120 Heidelberg, Germany

来源：

CELL | 2002年 / 108卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0092-8674(02)00627-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent advances have led to a new understanding of how mRNAs are exported from the nucleus to the cytoplasm. This process requires a heterodimeric mRNA export receptor that is part of an elaborate machinery conserved from yeast to humans. Export of mRNAs is coupled to upstream steps in gene expression, such as pre-mRNA splicing, and to downstream events, including nonsense-mediated decay.

引用

页码：523 / 531

页数：9

共 93 条

[1] Proteomic analysis of nucleoporin interacting proteins
Allen, NPC
Huang, L
Burlingame, A
Rexach, M
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (31) : 29268 - 29274
[2] The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates
Bachi, A
Braun, IC
Rodrigues, JP
Panté, N
Ribbeck, K
Von Kobbe, C
Kutay, U
Wilm, M
Görlich, D
Carmo-Fonseca, M
Izaurralde, E
[J]. RNA, 2000, 6 (01) : 136 - 158
[3] Structural basis for the interaction between FxFG nucleoporin repeats and importin-β in nuclear trafficking
Bayliss, R
Littlewood, T
Stewart, M
[J]. CELL, 2000, 102 (01) : 99 - 108
[4] Bear J, 1999, MOL CELL BIOL, V19, P6306
[5] Coupling RNA polymerase II transcription with pre-mRNA processing
Bentley, D
[J]. CURRENT OPINION IN CELL BIOLOGY, 1999, 11 (03) : 347 - 351
[6] Overexpression of TAP/p15 heterodimers bypasses nuclear retention and stimulates nuclear mRNA export
Braun, IC
Herold, A
Rode, M
Conti, E
Izaurralde, E
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (23) : 20536 - 20543
[7] Protein ligands to HuR modulate its interaction with target mRNAs in vivo
Brennan, CM
Gallouzi, IE
Steitz, JA
[J]. JOURNAL OF CELL BIOLOGY, 2000, 151 (01) : 1 - 13
[8] Pre-mRNA processing factors are required for nuclear export
Brodsky, AS
Silver, PA
[J]. RNA, 2000, 6 (12) : 1737 - 1749
[9] A MUTATION IN THE SCHIZOSACCHAROMYCES-POMBE RAE1 GENE CAUSES DEFECTS IN POLY(A)(+) RNA EXPORT AND IN THE CYTOSKELETON
BROWN, JA
BHARATHI, A
GHOSH, A
WHALEN, W
FITZGERALD, E
DHAR, R
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (13) : 7411 - 7419
[10] ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCR alpha enhancer function
Bruhn, L
Munnerlyn, A
Grosschedl, R
[J]. GENES & DEVELOPMENT, 1997, 11 (05) : 640 - 653

← 1 2 3 4 5 6 7 8 9 10 →