Serotonin 2A receptor mRNA levels in the neonatal dopamine-depleted rat striatum remain upregulated following suppression of serotonin hyperinnervation

被引：26

作者：

Basura, GJ

Walker, PD

机构：

[1] Wayne State Univ, Sch Med, Dept Anat & Cell Biol, Detroit, MI 48201 USA

[2] Wayne State Univ, Sch Med, Cellular & Clin Neurobiol Program, Dept Psychiat & Behav Neurosci, Detroit, MI 48201 USA

来源：

DEVELOPMENTAL BRAIN RESEARCH | 1999年 / 116卷 / 01期

关键词：

6-hydroxydopamine; 5,7-dihydroxytryptamine; in situ hybridization; serotonin 2C receptor; basal ganglia; substantia nigra; dorsal raphe;

D O I：

10.1016/S0165-3806(99)00066-8

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Sixty days after bilateral dopamine (DA) depletion (> 98%) with 6-hydroxydopamine (6-OHDA) in neonatal rats, serotonin (5-MT) content doubled and 5-HT2A receptor mRNA expression rose 54% within the rostral striatum. To determine if striatal 5-HT2A receptor mRNA upregulation is dependent on increased 5-HT levels following DA depletion, neonatal rats received dual injections of 6-OHDA and 5,7-dihydroxytryptamine (5,7-DHT) which suppressed 5-HT content by approximately 90%. In these 6-OHDA/5,7-DHT-treated rats, striatal 5-HT2A receptor mRNA expression was still elevated (87% above vehicle controls). Comparative analysis of 5-HT2A receptor mRNA expression yielded no significant changes in any experimental group. These results demonstrate that upregulated 5-HT2A receptor biosynthesis in the DA-depleted rat is not dependent on subsequent 5-HT hyperinnervation. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：111 / 117

页数：7

共 34 条

[1] I-125 LSD AUTORADIOGRAPHY CONFIRMS THE PREFERENTIAL LOCALIZATION OF CAUDATE-PUTAMEN-S2-RECEPTORS TO THE CAUDAL (PERIPALLIDAL) REGION [J].