Acute p-chloroamphetamine increases striatal preprotachykinin mRNA:: role of the serotonin 2A/2C receptor

被引：14

作者：

Gresch, PJ

Walker, PD

机构：

[1] Wayne State Univ, Sch Med, Dept Psychiat & Behav Neurosci, Cellular & Clin Neurobiol Program, Detroit, MI 48201 USA

[2] Wayne State Univ, Sch Med, Dept Anat & Cell Biol, Detroit, MI 48201 USA

来源：

MOLECULAR BRAIN RESEARCH | 1999年 / 67卷 / 01期

关键词：

dopamine; substance P; basal ganglia; alpha-methyl-p-tyrosine; ritanserin;

D O I：

10.1016/S0169-328X(99)00059-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Acute administration of p-chloroamphetamine (pCA) significantly increased (+90%) preprotachykinin (PPT) mRNA levels in the rat(2A/2C) receptor antagonist, ritanserin, blocked the pCA-induced increase in PPT mRNA levels. striatum. Administration of the serotonin alpha-Methyl-p-tyrosine pretreatment (alpha-MT, to reduce dopamine transmission) inhibited the pCA-induced increase in PPT mRNA levels. These results indicate that the pCa-induced increase in striatal PPT mRNA expression is mediated by serotonin(2A/2C) receptors but also requires dopamine tone. (C) 1999 Published by Elsevier Science B.V. All rights reserved.

引用

页码：190 / 193

页数：4

共 38 条

[1] AN INVIVO DIALYSIS AND BEHAVIORAL-STUDY OF THE RELEASE OF 5-HT BY PARA-CHLOROAMPHETAMINE IN RESERPINE-TREATED RATS [J].

ADELL, A ;

SARNA, GS ;

HUTSON, PH ;

CURZON, G .

BRITISH JOURNAL OF PHARMACOLOGY, 1989, 97 (01) :206-212

[2] I-125 LSD AUTORADIOGRAPHY CONFIRMS THE PREFERENTIAL LOCALIZATION OF CAUDATE-PUTAMEN-S2-RECEPTORS TO THE CAUDAL (PERIPALLIDAL) REGION [J].

ALTAR, CA ;

BOYAR, WC ;

MARIEN, MR .

BRAIN RESEARCH, 1986, 372 (01) :130-136

[3] STRIATAL TACHYKININ BIOSYNTHESIS - REGULATION OF MESSENGER-RNA AND PEPTIDE LEVELS BY DOPAMINE AGONISTS AND ANTAGONISTS [J].

BANNON, MJ ;

ELLIOTT, PJ ;

BUNNEY, EB .

MOLECULAR BRAIN RESEARCH, 1987, 3 (01) :31-37

[4]

BENLOUCIF S, 1993, J PHARMACOL EXP THER, V265, P373

[5] FACILITATION OF DOPAMINE RELEASE INVIVO BY SEROTONIN AGONISTS - STUDIES WITH MICRODIALYSIS [J].

BENLOUCIF, S ;

GALLOWAY, MP .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1991, 200 (01) :1-8

[6]

BHAT RV, 1993, J PHARMACOL EXP THER, V267, P496

[7]

CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2

[8] Carrier-dependent and Ca2+-dependent 5-HT and dopamine release induced by (+)-amphetamine, 3,4-methylendioxymethamphetamine, p-chloroamphetamine and(+)-fenfluramine [J].

Crespi, D ;

Mennini, T ;

Gobbi, M .

BRITISH JOURNAL OF PHARMACOLOGY, 1997, 121 (08) :1735-1743

[9] Serotonin depletion exacerbates changes in striatal gene expression following quinolinic acid injection [J].

Cummings, TJ ;

Walker, PD .

BRAIN RESEARCH, 1996, 743 (1-2) :240-248

[10]

EberleWang K, 1997, J COMP NEUROL, V384, P233, DOI 10.1002/(SICI)1096-9861(19970728)384:2<233::AID-CNE5>3.0.CO

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