Acute p-chloroamphetamine increases striatal preprotachykinin mRNA:: role of the serotonin 2A/2C receptor

被引：14

作者：

Gresch, PJ

Walker, PD

机构：

[1] Wayne State Univ, Sch Med, Dept Psychiat & Behav Neurosci, Cellular & Clin Neurobiol Program, Detroit, MI 48201 USA

[2] Wayne State Univ, Sch Med, Dept Anat & Cell Biol, Detroit, MI 48201 USA

来源：

MOLECULAR BRAIN RESEARCH | 1999年 / 67卷 / 01期

关键词：

dopamine; substance P; basal ganglia; alpha-methyl-p-tyrosine; ritanserin;

D O I：

10.1016/S0169-328X(99)00059-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Acute administration of p-chloroamphetamine (pCA) significantly increased (+90%) preprotachykinin (PPT) mRNA levels in the rat(2A/2C) receptor antagonist, ritanserin, blocked the pCA-induced increase in PPT mRNA levels. striatum. Administration of the serotonin alpha-Methyl-p-tyrosine pretreatment (alpha-MT, to reduce dopamine transmission) inhibited the pCA-induced increase in PPT mRNA levels. These results indicate that the pCa-induced increase in striatal PPT mRNA expression is mediated by serotonin(2A/2C) receptors but also requires dopamine tone. (C) 1999 Published by Elsevier Science B.V. All rights reserved.

引用

页码：190 / 193

页数：4

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