Repair of mitochondrial DNA in aging and carcinogenesis

被引：32

作者：

Berneburg, M

Kamenisch, Y

Krutmann, J

机构：

[1] Univ Tubingen, Dept Dermatol, D-72076 Tubingen, Germany

[2] Univ Dusseldorf, Inst Umweltmed Forsch gGmbH, D-40225 Dusseldorf, Germany

来源：

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES | 2006年 / 5卷 / 02期

关键词：

D O I：

10.1039/b507380d

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondria are responsible for the generation of energy in the form of adenosine triphosphate. These organelles contain their own genetic material, mitochondrial (mt) DNA. This mtDNA has been hypothesized to play a role in the processes of aging and carcinogenesis. Initial reports have shown that there is no repair of cyclobutylpyrimidine dimers (CPD). More recent reports indicate however, that the mitochondrion contains several defence mechanisms against endogenous or exogenous damaging agents such as ultraviolet radiation or oxidative damage. The role of these defence mechanisms in the removal of mitochondrial DNA damage and the link to aging and carcinogenesis-associated processes are discussed in this review.

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页码：190 / 198

页数：9

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