Simple method for rapid measurement of trichloroethylene and its major metabolites in biological samples

被引：24

作者：

Muralidhara, S ^{[1
]}

Bruckner, JV ^{[1
]}

机构：

[1] Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA

来源：

JOURNAL OF CHROMATOGRAPHY B | 1999年 / 732卷 / 01期

关键词：

trichloroethylene;

D O I：

10.1016/S0378-4347(99)00282-0

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A simple and rapid, yet sensitive technique was developed for concurrent measurement of trichloroethylene (TCE) and its major metabolites (i.e., trichloroacetic acid, trichloroethanol and dichloroacetic acid) in blood and in solid tissues. The method involves addition of an esterizer (water, sulfuric acid, methanol; 6:5:1; v/v/v) to blood or tissue homogenate in sealed vials, and subsequent gas chromatographic headspace analysis. The procedure should be useful in medical monitoring of TCE exposure as well as in experimental work, notably pharmacokinetic and pharmacodynamic studies pertaining to TCE carcinogenesis. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：145 / 153

页数：9

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