Aminophosphonates as organocatalysts in the direct asymmetric aldol reaction:: towards syn selectivity in the presence of Lewis bases

被引：79

作者：

Diner, Peter ^{[1
]}

Amedjkouh, Mohamed ^{[1
]}

机构：

[1] Univ Gothenburg, Dept Chem, SE-41296 Gothenburg, Sweden

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2006年 / 4卷 / 11期

关键词：

D O I：

10.1039/b605091c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chiral alpha-aminophosphonates have been synthesized and their performance was evaluated as organocatalysts in the direct asymmetric aldol reaction. High enantioselectivities ( up to 99% ee) were achieved for a range of substituted cyclohexanones and benzaldehydes. Several organic bases, such as DBU, DBN, and TMG, were used together with the alpha-aminophosphonates in the aldol reactions and were found to favor syn-selectivity.

引用

页码：2091 / 2096

页数：6

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