Nuclear transport mechanisms

被引:48
作者
Quimby, BB [1 ]
Corbett, AH [1 ]
机构
[1] Emory Univ, Sch Med, Dept Biochem, Atlanta, GA 30322 USA
关键词
nucleocytoplasmic transport; Ran; importin beta; nuclear transport factor 2 (NTF2); RNA export;
D O I
10.1007/PL00000816
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The term nuclear transport, refers to the movement of a large variety of macromolecules both into and out of the nucleus. Transport must be extremely selective, yet also very efficient. A single type of channel, the nuclear pore complex, mediates all movement across the nuclear envelope, Selectivity is achieved through the use of families of soluble factors that target substrates for import and export and deliver them to their appropriate intracellular destinations. We now have a fairly detailed understanding of the basic mechanisms of protein import into the nucleus. Many of these same principles can be applied to protein export and perhaps RNA export. This review will summarize the current status of what is known about various transport pathways and highlight the questions that remain to be answered.
引用
收藏
页码:1766 / 1773
页数:8
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