The Cdx-1 and Cdx-2 homeobox genes in the intestine

被引：170

作者：

Freund, JN ^{[1
]}

Domon-Dell, C ^{[1
]}

Kedinger, M ^{[1
]}

Duluc, I ^{[1
]}

机构：

[1] INSERM, U381, F-67200 Strasbourg, France

来源：

BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE | 1998年 / 76卷 / 06期

关键词：

caudal; epithelial cell proliferation and differentiation; cancer;

D O I：

10.1139/bcb-76-6-957

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The past years have witnessed an increasing number of reports relative to homeobox genes in endoderm-derived tissues. In this review, we focus on the caudal-related Cdx-1 and Cdx-2 homeobox genes to give an overview of the in vivo, in vitro, and ex vivo approaches that emphasize their primary role in intestinal development and in the control of intestinal cell proliferation, differentiation, and identity. The participation of these genes in colon tumorigenesis and their identification as important actors of the oncogenic process are also discussed.

引用

页码：957 / 969

页数：13

共 151 条

[41] LOCALIZATION OF THE GENES ENCODING 2 TRANSCRIPTION FACTORS, LMX1 AND CDX3, REGULATING INSULIN GENE-EXPRESSION TO HUMAN CHROMOSOME-1 AND CHROMOSOME-13
GERMAN, MS
WANG, JH
FERNALD, AA
ESPINOSA, R
LEBEAU, MM
BELL, GI
[J]. GENOMICS, 1994, 24 (02) : 403 - 404
[42] SYNERGISTIC ACTIVATION OF THE INSULIN GENE BY A LIM HOMEO DOMAIN PROTEIN AND A BASIC HELIX LOOP HELIX PROTEIN - BUILDING A FUNCTIONAL INSULIN MINIENHANCER COMPLEX
GERMAN, MS
WANG, JH
CHADWICK, RB
RUTTER, WJ
[J]. GENES & DEVELOPMENT, 1992, 6 (11) : 2165 - 2176
[43] INTESTINAL EPITHELIAL DIFFERENTIATION - NEW INSIGHTS FROM CHIMERIC AND TRANSGENIC MICE
GORDON, JI
[J]. JOURNAL OF CELL BIOLOGY, 1989, 108 (04) : 1187 - 1194
[44] GRABA Y, 1995, DEVELOPMENT, V121, P209
[45] Intron of the mouse Hoxa-7 gene contains conserved homeodomain binding sites that can function as an enhancer element in Drosophila
Haerry, TE
Gehring, WJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (24) : 13884 - 13889
[46] Haffen K, 1982, Prog Clin Biol Res, V85 Pt B, P261
[47] Regulation of sucrase and lactase in developing rats: Role of nuclear factors that bind to two gene regulatory elements
Hecht, A
Torbey, CF
Korsmo, HA
Olsen, WA
[J]. GASTROENTEROLOGY, 1997, 112 (03) : 803 - 812
[48] Misexpression of the pancreatic homeodomain protein IDX-1 by the Hoxa-4 promoter associated with agenesis of the cecum
Heller, RS
Stoffers, DA
Hussain, MA
Miller, CP
Habener, JF
[J]. GASTROENTEROLOGY, 1998, 115 (02) : 381 - 387
[49] Henning S.J., 1987, PHYSL GASTROINTESTIN, P285
[50] Hlx homeo box gene is essential for an inductive tissue interaction that drives expansion of embryonic liver and gut
Hentsch, B
Lyons, I
Li, RL
Hartley, L
Lints, TJ
Adams, JM
Harvey, RP
[J]. GENES & DEVELOPMENT, 1996, 10 (01) : 70 - 79

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