Hypertriglyceridemia as a possible risk factor for prostate cancer

被引:59
作者
Wuermli, L
Joerger, M
Henz, S
Schmid, HP
Riesen, WF
Thomas, G
Krek, W
Cerny, T
Gillessen, S
机构
[1] Kantonsspital, Dept Internal Med, CH-9007 St Gallen, Switzerland
[2] Antoni Van Leeuwenhoek Hosp, Netherlands Canc Inst, Div Expt Therapy, Amsterdam, Netherlands
[3] Kantonsspital, Dept Urol, CH-9007 St Gallen, Switzerland
[4] Kantonsspital, Dept Clin Chem & Hematol, CH-9007 St Gallen, Switzerland
[5] Univ Cincinnati, Genome Res Inst, Cincinnati, OH 45221 USA
[6] ETH Honggerberg, Inst Cell Biol, CH-8093 Zurich, Switzerland
[7] Kantonsspital, Dept Med Oncol, CH-9007 St Gallen, Switzerland
关键词
hyperlipidemia; serum cholesterol; serum triglycerides;
D O I
10.1038/sj.pcan.4500834
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
We retrospectively studied anthropometric and laboratory parameters ( including serum triglycerides, cholesterol), as well as comedication in 504 patients diagnosed with prostate cancer between January 1997 and August 2002 at a single referral center, and compared these patients with 565 age-matched patients with benign prostatic hyperplasia. A positive correlation was found between serum triglycerides and prostate cancer ( odds ratio: 1.148/ mmol/ l; 95% confidence interval (CI) 1.003 - 1.315; P<0.05) after correcting for age, body mass index, diabetes and comedication with statins. Hypertriglyceridemia may increase the risk of prostate cancer, and the prognostic relevancy of serum triglycerides should be studied prospectively.
引用
收藏
页码:316 / 320
页数:5
相关论文
共 33 条
[11]  
Harvei S, 1997, INT J CANCER, V71, P545, DOI 10.1002/(SICI)1097-0215(19970516)71:4<545::AID-IJC7>3.0.CO
[12]  
2-U
[13]   NUTRITION AND PROSTATE-CANCER - A CASE-CONTROL STUDY [J].
HESHMAT, MY ;
KAUL, L ;
KOVI, J ;
JACKSON, MA ;
JACKSON, AG ;
JONES, GW ;
EDSON, M ;
ENTERLINE, JP ;
WORRELL, RG ;
PERRY, SL .
PROSTATE, 1985, 6 (01) :7-17
[14]  
International Agency for Research on Cancer: WHO, 2002, IARC HDB CANC PREV W
[15]   Cancer statistics, 2003 [J].
Jemal, A ;
Murray, T ;
Samuels, A ;
Ghafoor, A ;
Ward, E ;
Thun, MJ .
CA-A CANCER JOURNAL FOR CLINICIANS, 2003, 53 (01) :5-26
[16]   DIET AND PROSTATIC-CANCER - A CASE-CONTROL STUDY IN HAWAII [J].
KOLONEL, LN ;
YOSHIZAWA, CN ;
HANKIN, JH .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1988, 127 (05) :999-1012
[17]   Nutrition and prostate cancer [J].
Kolonel, LN .
CANCER CAUSES & CONTROL, 1996, 7 (01) :83-94
[18]   Manganese superoxide dismutase polymorphism, prediagnostic antioxidant status, and risk of clinical significant prostate cancer [J].
Li, HJ ;
Kantoff, PW ;
Giovannucci, E ;
Leitzmann, MF ;
Gaziano, JN ;
Stampfer, MJ ;
Ma, J .
CANCER RESEARCH, 2005, 65 (06) :2498-2504
[19]   Risk factors for clinical benign prostatic hyperplasia in a community-based population of healthy aging men [J].
Meigs, JB ;
Mohr, B ;
Barry, MJ ;
Collins, MM ;
McKinlay, JB .
JOURNAL OF CLINICAL EPIDEMIOLOGY, 2001, 54 (09) :935-944
[20]   A prospective study on intake of animal products and risk of prostate cancer [J].
Michaud, DS ;
Augustsson, K ;
Rimm, EB ;
Stampfer, MJ ;
Willett, WC ;
Giovannucci, E .
CANCER CAUSES & CONTROL, 2001, 12 (06) :557-567