Reactivity-based one-pot synthesis of the tumor-associated antigen N3 minor octasaccharide for the development of a photocleavable DIOS-MS sugar array

被引：50

作者：

Lee, JC

Wit, CY

Apon, JV

Siuzdak, G

Wong, CH

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[3] Acad Sinica, Genom Res Ctr, Taipei 11529, Taiwan

[4] Scripps Res Inst, Dept Mol Biol & Chem, La Jolla, CA 92037 USA

[5] Scripps Res Inst, Scripps Ctr Mass Spectrometry, La Jolla, CA 92037 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 17期

关键词：

D O I：

10.1002/anie.200504067

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Sweet and light: Readily available thioglycosides with defined relative reactivity values were used as building blocks in a one-pot strategy to synthesize the tumor-associated carbohydrate antigen N3 minor (1). The target molecule was attached covalently to a porous silicon surface through a photocleavable linker for direct characterization in a mass spectrometer equipped with a laser source. (Chemical Equation Presented). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2753 / 2757

页数：5

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