共 24 条
The marijuana component cannabidiol inhibits β-amyloid-induced tau protein hyperphosphorylation through Wnt/β-catenin pathway rescue in PC12 cells
被引:195
作者:
Esposito, G
[1
]
De Filippis, D
[1
]
Carnuccio, R
[1
]
Izzo, AA
[1
]
Iuvone, T
[1
]
机构:
[1] Univ Naples Federico II, Fac Pharm, Dept Expt Pharmacol, I-80131 Naples, Italy
来源:
JOURNAL OF MOLECULAR MEDICINE-JMM
|
2006年
/
84卷
/
03期
关键词:
Alzheimer's disease;
beta-amyloid (A beta) peptide;
cannabidiol;
tau protein;
GSK-3;
beta;
PC12;
cells;
D O I:
10.1007/s00109-005-0025-1
中图分类号:
Q3 [遗传学];
学科分类号:
071007 ;
090102 ;
摘要:
Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder. A massive accumulation of beta-amyloid (A beta) peptide aggregates has been proposed as pivotal event in AD. A beta-induced toxicity is accompanied by a variegated combination of events including oxidative stress. The Wnt pathway has multiple actions in the cascade of events triggered by A beta, and drugs that rescue Wnt activity may be considered as novel therapeutics for AD treatment. Cannabidiol, a non-psychoactive marijuana component, has been recently proposed as an antioxidant neuroprotective agent in neurodegenerative diseases. Moreover, it has been shown to rescue PC12 cells from toxicity induced by A beta peptide. However, the molecular mechanism of cannabidiol-induced neuroprotective effect is still unknown. Here, we report that cannabidiol inhibits hyperphosphorylation of tau protein in A beta-stimulated PC12 neuronal cells, which is one of the most representative hallmarks in AD. The effect of cannabidiol is mediated through the Wnt/beta-catenin pathway rescue in A beta-stimulated PC12 cells. These results provide new molecular insight regarding the neuroprotective effect of cannabidiol and suggest its possible role in the pharmacological management of AD, especially in view of its low toxicity in humans.
引用
收藏
页码:253 / 258
页数:6
相关论文