Synthesis and pharmacological activity of diarylindole derivatives.: Cytotoxic agents based on combretastatins

被引：57

作者：

Medarde, M

Ramos, AC

Caballero, E

de Clairac, RPL

López, JL

Grávalos, DG

Feliciano, AS

机构：

[1] Fac Farm, Lab Quim Organ & Farmaceut, Salamanca 37007, Spain

[2] Pharma Mar SA, Madrid 28780, Spain

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 16期

关键词：

D O I：

10.1016/S0960-894X(99)00370-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Taking into account the structure of Combretastatins, we have synthesized and assayed for cytotoxic activity of new indole derivatives. Two aryl groups are maintained in the cis orientation required for activity by means of an indole moiety built up on less active ketoderivatives used as starting materials. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2303 / 2308

页数：6

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