EpCAM: Another Surface-to-Nucleus Missile

被引：68

作者：

Carpenter, Graham ^{[1
]}

Brewer, Monica Red ^{[1
]}

机构：

[1] Vanderbilt Univ, Sch Med, Dept Biochem, Nashville, TN 37232 USA

来源：

CANCER CELL | 2009年 / 15卷 / 03期

关键词：

EP-CAM; ANTIGEN;

D O I：

10.1016/j.ccr.2009.02.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The epithelial-specific cell adhesion molecule (EpCAM) modulates cell adhesion and proliferation. Its overexpression correlates with tumor cell proliferation, and EpCAM is a therapeutic target. In the February issue of Nature Cell Biology, Maetzel et al. demonstrate that proliferative responses to EpCAM require regulated intramembrane proteolysis and a nucleocytoplasmic intracellular domain fragment.

引用

收藏

页码：165 / 166

页数：2

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