The Prevalence of Diverse HIV-1 Strains Was Stable in Cameroonian Blood Donors From 1996 to 2004

被引：67

作者：

Brennan, Catherine A. ^{[1
]}

Bodelle, Pierre ^{[1
]}

Coffey, Ruthie ^{[1
]}

Devare, Sushil C. ^{[1
]}

Golden, Alan ^{[1
]}

Hackett, John, Jr. ^{[1
]}

Harris, Barbara ^{[1
]}

Holzmayer, Vera ^{[1
]}

Luk, Ka-Cheung ^{[1
]}

Schochetman, Gerald ^{[1
]}

Swanson, Priscilla ^{[1
]}

Yamuguchi, Julie ^{[1
]}

Vallari, Ana ^{[1
]}

Ndembi, Nicaise ^{[2
]}

Ngansop, Charlotte ^{[2
]}

Makamche, Florence ^{[2
]}

Mbanya, Dora ^{[2
]}

Guertler, Lutz G. ^{[3
]}

Zekeng, Leopold ^{[4
]}

Kaptue, Lazare ^{[2
,5
]}

机构：

[1] Abbott Diagnost, AIDS Res & Virus Discovery, Dept 09NG, Abbott Pk, IL 60064 USA

[2] Univ Yaounde, Dept Hematol, Yaounde, Cameroon

[3] Ernst Moritz Arndt Univ Greifswald, Loeffler Inst, Greifswald, Germany

[4] UNAIDS, Accra, Ghana

[5] Univ Montagnes, Lab Hematol & Immunol, Bangangte, Cameroon

来源：

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2008年 / 49卷 / 04期

关键词：

Cameroon; HIV-1; strain diversity; strain prevalence;

D O I：

10.1097/QAI.0b013e31818a6561

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Objective: The HIV epidemic in Cameroon is characterized by a high level of strain diversity despite a relatively low prevalence of infection. In this study. HIV strains inflecting blood donors in Cameroon were characterized to determine the prevalence of subtypes and intersubtype recombinants and if strain prevalence was changing over time. Methods: From 1996 through 2004, 676 HIV-infected blood donations were collected at blood banks in Douala and Yaounde, Cameroon. A subset of the HIV-1 group M strains (n = 574) were classified based on phylogenetic analysis of viral sequences from the gag p24, pol integrase, and em gp41 regions. Results: HIV-1 group M accounted for 97.3% (n = 658) of infections. whereas group O was present in 2.2% (n = 15) and HIV-2 in 0.4% (n = 3). Within the group M infections, 14 subtypes and circulating recombinant forms (CRFs) and unique recombinant forms (URFs) were identified. Overall. CRF02_AG accounted for 58.2% of infections, URFs 14.8%, and levels of subtypes, A, B, C, D, F2, and G, and CRFs, 01, 06, 09, 11, 13. 22, and 37, varied from 0.2% to 6.1%. Evaluation of HIV strains present in the donor population over this 9-year period shoved no substantial changes in the proportion of infections caused by each subtype and CRF, the percentage of intersubtype recombinants, or the strain composition of the URFs. Conclusions: HIV-1 strain diversity in Cameroon did not significantly change, suggesting a mature and relatively stable epidemic.

引用

页码：432 / 439

页数：8

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